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• W1596689072 endingPage "5821" @default.
• W1596689072 startingPage "5815" @default.
• W1596689072 abstract "ABSTRACT Zinc is an essential nutrient for all cells, but remarkably little is known regarding bacterial zinc transport and its regulation. We have identified three of the key components acting to maintain zinc homeostasis in Bacillus subtilis . Zur is a metalloregulatory protein related to the ferric uptake repressor (Fur) family of regulators and is required for the zinc-specific repression of two operons implicated in zinc uptake, yciC and ycdHIyceA . A zur mutant overexpresses the 45-kDa YciC membrane protein, and purified Zur binds specifically, and in a zinc-responsive manner, to an operator site overlapping the yciC control region. A similar operator precedes the ycdH -containing operon, which encodes an ABC transporter. Two lines of evidence suggest that the ycdH operon encodes a high-affinity zinc transporter whereas YciC may function as part of a lower-affinity pathway. First, a ycdH mutant is impaired in growth in low-zinc medium, and this growth defect is exacerbated by the additional presence of a yciC mutation. Second, mutation of ycdH , but not yciC , alters the regulation of both the yciC and ycdH operons such that much higher levels of exogenous zinc are required for repression. We conclude that Zur is a Fur-like repressor that controls the expression of two zinc homeostasis operons in response to zinc. Thus, Fur-like regulators control zinc homeostasis in addition to their previously characterized roles in regulating iron homeostasis, acid tolerance responses, and oxidative stress functions." @default.
• W1596689072 created "2016-06-24" @default.
• W1596689072 creator A5016572389 @default.
• W1596689072 creator A5032712331 @default.
• W1596689072 date "1998-11-15" @default.
• W1596689072 modified "2023-10-07" @default.
• W1596689072 title "Identification of a Zinc-Specific Metalloregulatory Protein, Zur, Controlling Zinc Transport Operons in <i>Bacillus subtilis</i>" @default.
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• W1596689072 doi "https://doi.org/10.1128/jb.180.22.5815-5821.1998" @default.
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