FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1596806083> ?p ?o ?g. }

• W1596806083 endingPage "36" @default.
• W1596806083 startingPage "36" @default.
• W1596806083 abstract "Streptococcus pneumoniae is the leading cause of bacterial meningitis. Pneumococcal meningitis is associated with the highest mortality among bacterial meningitis and it may also lead to neurological sequelae despite the use of antibiotic therapy. Experimental animal models of pneumococcal meningitis are important to study the pathogenesis of meningitis, the host immune response induced after infection, and the efficacy of novel drugs and vaccines. In the present work, we describe in detail a simple, reproducible and efficient method to induce pneumococcal meningitis in outbred mice by using the intracranial subarachnoidal route of infection. Bacteria were injected into the subarachnoid space through a soft point located 3.5 mm rostral from the bregma. The model was tested with several doses of pneumococci of three capsular serotypes (2, 3 and 4), and mice survival was recorded. Lethal doses killing 50 % of animals infected with type 2, 3 and 4 S. pneumoniae were 3.2 × 10, 2.9 × 10 and 1.9 × 102 colony forming units, respectively. Characterisation of the disease caused by the type 4 strain showed that in moribund mice systemic dissemination of pneumococci to blood and spleen occurred. Histological analysis of the brain of animals infected with type 4 S. pneumoniae proved the induction of meningitis closely resembling the disease in humans. The proposed method for inducing pneumococcal meningitis in outbred mice is easy-to-perform, fast, cost-effective, and reproducible, irrespective of the serotype of pneumococci used." @default.
• W1596806083 created "2016-06-24" @default.
• W1596806083 creator A5017138457 @default.
• W1596806083 creator A5027192448 @default.
• W1596806083 creator A5034235296 @default.
• W1596806083 creator A5037002872 @default.
• W1596806083 creator A5055064024 @default.
• W1596806083 creator A5061355599 @default.
• W1596806083 creator A5064694313 @default.
• W1596806083 creator A5079745542 @default.
• W1596806083 date "2004-01-01" @default.
• W1596806083 modified "2023-10-01" @default.
• W1596806083 cites W1482276319 @default.
• W1596806083 cites W1549694950 @default.
• W1596806083 cites W1558382152 @default.
• W1596806083 cites W1895102180 @default.
• W1596806083 cites W1946326232 @default.
• W1596806083 cites W1986513215 @default.
• W1596806083 cites W1986809510 @default.
• W1596806083 cites W1991694118 @default.
• W1596806083 cites W1995363060 @default.
• W1596806083 cites W2011029038 @default.
• W1596806083 cites W2017436249 @default.
• W1596806083 cites W2017492126 @default.
• W1596806083 cites W2023000404 @default.
• W1596806083 cites W2024840188 @default.
• W1596806083 cites W2032744235 @default.
• W1596806083 cites W2042485189 @default.
• W1596806083 cites W2047278228 @default.
• W1596806083 cites W2048721933 @default.
• W1596806083 cites W2049300787 @default.
• W1596806083 cites W205382369 @default.
• W1596806083 cites W2058991170 @default.
• W1596806083 cites W2065826968 @default.
• W1596806083 cites W2075857379 @default.
• W1596806083 cites W2079444284 @default.
• W1596806083 cites W2079792424 @default.
• W1596806083 cites W2096221524 @default.
• W1596806083 cites W2098109099 @default.
• W1596806083 cites W2103516617 @default.
• W1596806083 cites W2108360478 @default.
• W1596806083 cites W2110750635 @default.
• W1596806083 cites W2110888813 @default.
• W1596806083 cites W2112104975 @default.
• W1596806083 cites W2115914830 @default.
• W1596806083 cites W2117606701 @default.
• W1596806083 cites W2119027871 @default.
• W1596806083 cites W2125201285 @default.
• W1596806083 cites W2126290851 @default.
• W1596806083 cites W2129303639 @default.
• W1596806083 cites W2138498125 @default.
• W1596806083 cites W2140524246 @default.
• W1596806083 cites W2144451025 @default.
• W1596806083 cites W2146484568 @default.
• W1596806083 cites W2148525358 @default.
• W1596806083 cites W2149113229 @default.
• W1596806083 cites W2159861178 @default.
• W1596806083 cites W2160501504 @default.
• W1596806083 cites W2161683931 @default.
• W1596806083 cites W2164692599 @default.
• W1596806083 cites W2165177024 @default.
• W1596806083 cites W2167209993 @default.
• W1596806083 cites W2167435540 @default.
• W1596806083 cites W2464713997 @default.
• W1596806083 cites W2472182922 @default.
• W1596806083 doi "https://doi.org/10.1186/1471-2180-4-36" @default.
• W1596806083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/524167" @default.
• W1596806083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15385055" @default.
• W1596806083 hasPublicationYear "2004" @default.
• W1596806083 type Work @default.
• W1596806083 sameAs 1596806083 @default.
• W1596806083 citedByCount "27" @default.
• W1596806083 countsByYear W15968060832013 @default.
• W1596806083 countsByYear W15968060832014 @default.
• W1596806083 countsByYear W15968060832015 @default.
• W1596806083 countsByYear W15968060832016 @default.
• W1596806083 countsByYear W15968060832017 @default.
• W1596806083 countsByYear W15968060832018 @default.
• W1596806083 countsByYear W15968060832019 @default.
• W1596806083 countsByYear W15968060832021 @default.
• W1596806083 countsByYear W15968060832022 @default.
• W1596806083 countsByYear W15968060832023 @default.
• W1596806083 crossrefType "journal-article" @default.
• W1596806083 hasAuthorship W1596806083A5017138457 @default.
• W1596806083 hasAuthorship W1596806083A5027192448 @default.
• W1596806083 hasAuthorship W1596806083A5034235296 @default.
• W1596806083 hasAuthorship W1596806083A5037002872 @default.
• W1596806083 hasAuthorship W1596806083A5055064024 @default.
• W1596806083 hasAuthorship W1596806083A5061355599 @default.
• W1596806083 hasAuthorship W1596806083A5064694313 @default.
• W1596806083 hasAuthorship W1596806083A5079745542 @default.
• W1596806083 hasBestOaLocation W15968060831 @default.
• W1596806083 hasConcept C10389963 @default.
• W1596806083 hasConcept C141071460 @default.
• W1596806083 hasConcept C159047783 @default.
• W1596806083 hasConcept C169760540 @default.
• W1596806083 hasConcept C203014093 @default.
• W1596806083 hasConcept C2776152631 @default.

• next