Matches in SemOpenAlex for { <https://semopenalex.org/work/W1596886411> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1596886411 endingPage "125" @default.
- W1596886411 startingPage "102" @default.
- W1596886411 abstract "The immune system is hierarchical and has many levels, exhibiting much emergent behaviour. However, at its heart are molecular recognition events that are indistinguishable from other types of biomacromolecular interaction. These can be addressed well by quantitative experimental and theoretical biophysical techniques, and particularly by methods from drug design. We review here our approach to computational immunovaccinology. In particular, we describe the JenPep database and two new techniques for T cell epitope prediction. One is based on quantitative structure-activity relationships (a 3D-QSAR method based on CoMSIA and another 2D method based on the Free-Wilson approach) and the other on atomistic molecular dynamic simulations using high performance computing. JenPep (http://www.jenner.ar.uk/ JenPep) is a relational database system supporting quantitative data on peptide binding to major histocompatibility complexes, TAP transporters, TCR-pMHC complexes, and an annotated list of B cell and T cell epitopes. Our 2D-QSAR method factors the contribution to peptide binding from individual amino acids as well as 1-2 and 1-3 residue interactions. In the 3D-QSAR approach, the influence of five physicochemical properties (volume, electrostatic potential, hydrophobicity, hydrogen-bond donor and acceptor abilities) on peptide affinity were considered. Both methods are exemplified through their application to the well-studied problem of peptide binding to the human class I MHC molecule HLA-A*0201." @default.
- W1596886411 created "2016-06-24" @default.
- W1596886411 creator A5015400421 @default.
- W1596886411 creator A5019523089 @default.
- W1596886411 creator A5019742969 @default.
- W1596886411 creator A5025618591 @default.
- W1596886411 creator A5052238096 @default.
- W1596886411 creator A5052912254 @default.
- W1596886411 creator A5063192101 @default.
- W1596886411 creator A5066453821 @default.
- W1596886411 creator A5080865281 @default.
- W1596886411 creator A5085628631 @default.
- W1596886411 creator A5087166612 @default.
- W1596886411 date "2003-10-16" @default.
- W1596886411 modified "2023-09-23" @default.
- W1596886411 title "Computational Vaccinology: Quantitative Approaches" @default.
- W1596886411 doi "https://doi.org/10.1002/0470090766.ch8" @default.
- W1596886411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14712934" @default.
- W1596886411 hasPublicationYear "2003" @default.
- W1596886411 type Work @default.
- W1596886411 sameAs 1596886411 @default.
- W1596886411 citedByCount "15" @default.
- W1596886411 countsByYear W15968864112014 @default.
- W1596886411 countsByYear W15968864112016 @default.
- W1596886411 countsByYear W15968864112017 @default.
- W1596886411 countsByYear W15968864112023 @default.
- W1596886411 crossrefType "other" @default.
- W1596886411 hasAuthorship W1596886411A5015400421 @default.
- W1596886411 hasAuthorship W1596886411A5019523089 @default.
- W1596886411 hasAuthorship W1596886411A5019742969 @default.
- W1596886411 hasAuthorship W1596886411A5025618591 @default.
- W1596886411 hasAuthorship W1596886411A5052238096 @default.
- W1596886411 hasAuthorship W1596886411A5052912254 @default.
- W1596886411 hasAuthorship W1596886411A5063192101 @default.
- W1596886411 hasAuthorship W1596886411A5066453821 @default.
- W1596886411 hasAuthorship W1596886411A5080865281 @default.
- W1596886411 hasAuthorship W1596886411A5085628631 @default.
- W1596886411 hasAuthorship W1596886411A5087166612 @default.
- W1596886411 hasConcept C104317684 @default.
- W1596886411 hasConcept C147483822 @default.
- W1596886411 hasConcept C147597530 @default.
- W1596886411 hasConcept C164126121 @default.
- W1596886411 hasConcept C167625842 @default.
- W1596886411 hasConcept C185592680 @default.
- W1596886411 hasConcept C195616568 @default.
- W1596886411 hasConcept C207936829 @default.
- W1596886411 hasConcept C2779281246 @default.
- W1596886411 hasConcept C2994376932 @default.
- W1596886411 hasConcept C41008148 @default.
- W1596886411 hasConcept C54355233 @default.
- W1596886411 hasConcept C55493867 @default.
- W1596886411 hasConcept C59593255 @default.
- W1596886411 hasConcept C70721500 @default.
- W1596886411 hasConcept C71240020 @default.
- W1596886411 hasConcept C86803240 @default.
- W1596886411 hasConceptScore W1596886411C104317684 @default.
- W1596886411 hasConceptScore W1596886411C147483822 @default.
- W1596886411 hasConceptScore W1596886411C147597530 @default.
- W1596886411 hasConceptScore W1596886411C164126121 @default.
- W1596886411 hasConceptScore W1596886411C167625842 @default.
- W1596886411 hasConceptScore W1596886411C185592680 @default.
- W1596886411 hasConceptScore W1596886411C195616568 @default.
- W1596886411 hasConceptScore W1596886411C207936829 @default.
- W1596886411 hasConceptScore W1596886411C2779281246 @default.
- W1596886411 hasConceptScore W1596886411C2994376932 @default.
- W1596886411 hasConceptScore W1596886411C41008148 @default.
- W1596886411 hasConceptScore W1596886411C54355233 @default.
- W1596886411 hasConceptScore W1596886411C55493867 @default.
- W1596886411 hasConceptScore W1596886411C59593255 @default.
- W1596886411 hasConceptScore W1596886411C70721500 @default.
- W1596886411 hasConceptScore W1596886411C71240020 @default.
- W1596886411 hasConceptScore W1596886411C86803240 @default.
- W1596886411 hasLocation W15968864111 @default.
- W1596886411 hasLocation W15968864112 @default.
- W1596886411 hasOpenAccess W1596886411 @default.
- W1596886411 hasPrimaryLocation W15968864111 @default.
- W1596886411 hasRelatedWork W1558421445 @default.
- W1596886411 hasRelatedWork W1587907511 @default.
- W1596886411 hasRelatedWork W1596377987 @default.
- W1596886411 hasRelatedWork W1970557199 @default.
- W1596886411 hasRelatedWork W2166570238 @default.
- W1596886411 hasRelatedWork W2374411563 @default.
- W1596886411 hasRelatedWork W26090337 @default.
- W1596886411 hasRelatedWork W2953549230 @default.
- W1596886411 hasRelatedWork W3031211151 @default.
- W1596886411 hasRelatedWork W4200059034 @default.
- W1596886411 isParatext "false" @default.
- W1596886411 isRetracted "false" @default.
- W1596886411 magId "1596886411" @default.
- W1596886411 workType "other" @default.