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• W1596964951 abstract "Prenatal screening for Down syndrome and other aneuploidies, such as trisomies 13 and 18, has advanced significantly since its advent in the 1980s. Historically, women 35 years or older were offered prenatal genetic counseling and the option of a diagnostic test such as chorionic villus sampling or amniocentesis. With this screening approach, only 20% of the fetal Down syndrome population are detected antenatally. Sonographic and biochemical markers are now employed to screen for aneuploidies and neural tube defects in the first and second trimester. Maternal serum screening for Down syndrome in the second trimester started in the mid-1980s, with low levels of the analyte α-fetoprotein associated with an increased risk of fetal Down syndrome. Today, an increased nuchal translucency in the first trimester and/or a thickened nuchal fold in the second trimester are highly specific sonographic markers in trisomy 21 fetuses. Prenatal diagnosis should be made available, if requested, after appropriate counseling, including risks and benefits, to all pregnant women, regardless of maternal age." @default.
• W1596964951 created "2016-06-24" @default.
• W1596964951 creator A5030836937 @default.
• W1596964951 creator A5063144886 @default.
• W1596964951 date "2012-01-04" @default.
• W1596964951 modified "2023-10-14" @default.
• W1596964951 title "First‐ and Second‐Trimester Screening for Fetal Aneuploidy and Neural Tube Defects" @default.
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• W1596964951 doi "https://doi.org/10.1002/9781119963783.ch7" @default.
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