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- W1596996258 abstract "Publisher Summary This chapter describes recent advances made in the use of antibody drug conjugates for cancer therapy. In the past few years, monoclonal antibodies (mAbs) and mAb-based reagents have demonstrated considerable utility in the clinical treatment of cancer. While the use of mAb-drug conjugates for cancer therapy is conceptually appealing, significant limitations have been identified. Recent work in the field has focused on chimeric and humanized mAbs that are relatively nonimmunogenic and have high affinities for tumor associated antigens. The focus is also on mAbs that are efficiently internalized into cells once they bind to the target antigen, engineered mAbs that are designed for efficient drug delivery, new drugs with high potencies, and linker technology to accommodate these novel agents. The chapter discusses mAb-drug conjugates that have shown particular promise in preclinical tumor models and are either moving forward toward clinical trials, or are currently in clinical trials. One of the agents, Mylotarg, has recently been approved for treating acute myelogenous leukemia and represents the first clinically approved mAb-drug conjugate for the treatment of cancer. The chapter also discusses hydrazone-linked conjugates, anti-CD33-calicheamicin conjugates, and disulfide-linked conjugates." @default.
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- W1596996258 date "2003-01-01" @default.
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- W1596996258 title "Chapter 23. Recent advances in antibody drug conjugates for cancer therapy" @default.
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- W1596996258 doi "https://doi.org/10.1016/s0065-7743(03)38024-8" @default.
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