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- W1597008252 abstract "Abstract New Zealand White rabbits were immunized subcutaneously with partially purified UV-inactivated preparations of herpes simplex virus (HSV-1 or HSV-2) in complete Freund's adjuvant. After the initial immunizations, designated groups of animals received additional amounts of either HSV-1 or HSV-2 at 35-day intervals. Sera were absorbed with lysates of cells infected with heterotypic virus and the residual monotypic antibodies were detected by 51Cr-release assay using HSV-infected target cells. A positive correlation was found between the ratio of neutralizing antibodies to HSV-1 and HSV-2 (II/I index) and the content of monotypic antibodies. Results showed that production of monotypic antibodies to HSV-1 and HSV-2, under the conditions employed, was independent of previous exposure to HSV." @default.
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- W1597008252 date "1976-04-01" @default.
- W1597008252 modified "2023-09-25" @default.
- W1597008252 title "Effect of Cross-Immunization on Monotypic Antibody Responses to Herpes Simplex Virus Types 1 and 2" @default.
- W1597008252 doi "https://doi.org/10.4049/jimmunol.116.4.898" @default.
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