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- W1597018293 abstract "It is well established from animal and human studies that suboptimal environmental exposures during fetal and early postnatal life can have long-term effects on metabolic health, including the risk of developing type 2 diabetes and obesity. Nevertheless, the mechanisms by which an event in early life can have phenotypic effects many years later, following multiple rounds of cell division are poorly defined. Alterations in epigenetic modifications are emerging as a plausible mechanism underlying such developmental programming, not least because they are normally retained following mitotic cell division. There is good evidence showing that epigenetic patterns are altered by early environmental factors known to be associated with obesity or type 2 diabetes. Since these changes in epigenotype are present in early postnatal life, they could represent biomarkers of disease risk. If a causal relationship between changes in the epigenotype and long-term health causality can be established, this raises the possibility of also using epigenetic changes as therapeutic targets for intervention and prevention.KeywordsBiomarkersDiabetesGrowth patternsMaternal dietNutritionProgramming" @default.
- W1597018293 created "2016-06-24" @default.
- W1597018293 creator A5015478687 @default.
- W1597018293 creator A5022346666 @default.
- W1597018293 creator A5084467295 @default.
- W1597018293 date "2013-01-01" @default.
- W1597018293 modified "2023-09-24" @default.
- W1597018293 title "Developmental Epigenetic Programming in Diabetes and Obesity" @default.
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- W1597018293 doi "https://doi.org/10.1007/978-3-642-36827-1_11" @default.
- W1597018293 hasPublicationYear "2013" @default.