FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597029785> ?p ?o ?g. }

• W1597029785 endingPage "A124" @default.
• W1597029785 startingPage "A124" @default.
• W1597029785 abstract "This article was originally published online on 8 April 2015BackgroundIgE mediated cow´s milk allergy (CMA) is a frequent disease in pediatric population, and challenge tests are considered gold standard in its diagnosis, although its use is limited in clinical practice. An appropriated anamnesis and laboratorial analysis are the most frequent and feasible used tools. The aim of this study was to evaluate the role of these practices in IgE mediated CMA diagnosis.MethodsIt was a retrospective study based on patient data charts from a reference center in food allergy. All patients who performed open, single or double blind placebo controlled oral food challenges (OFC) for CMA diagnosis were included. Clinical history was defined as suggestive when patients presented at any time anaphylaxis, urticaria, angioedema, laryngeal edema and dyspnea. Diarrhea, vomiting, cough, wheezing, rhinoconjunctivitis, pruritus and erythema were considered as dubious. Symptoms onset <2 hours after food ingestion was also considered suggestive. Dubious and/or subjective symptoms or delayed ones were considered undetermined. Specific IgE (sIgE) was included when evaluated ± 12 months from OFC. Skin prick test was considered positive when wheal was >3mm and/or serum specific IgE >0.35 kU/L. Sensitivity (Se), specificity (Sp), positive and negative predictive value (PPV and NPV) and likelihood ratio (LR) were established, comparing anamnesis, anaphylaxis, laboratorial tests versus OFC.Results92 patients were included (43 OFC+; 49 OFC-). The median age at challenge test was 2.5 years (0.4-10.7) (OFC+ 3.0y; OFC- 2.4y). The median time between symptoms onset and food challenge was 2.3 years (0.2-10.4) (OFC+ 2.7; OFC- 2.2). Suggestive clinical history was present in 93% of patients in OFC+, compared to 61% of patients in OFC- (Se 93%; Sp 38%; PPV 57%; NPV 86%; LR 1.51; p<0.05). Considering only anaphylactic symptoms versus OFC the results were Se 44%; Sp 87%; PPV 76%; NPV 64% and LR 3.06 (p<0.05). Specific IgE was present in 100% of patients in OFC+ resulting in Se 100%; Sp 48%; PPV 63%; NPV 100% and LR 1.96 (p<0.05). Suggestive clinical history associated with symptoms onset <2 hours and presence of sIgE demonstrated a Se 88%; Sp 73%; PPV 74%; NPV 88% and LR 3.3 (p<0.05).ConclusionsSuggestive clinical history associated to positive sIgE was helpful on the diagnosis of CMA. Generally, the OFC remains necessary to set or exclude diagnosis. Negative sIgE was useful to exclude CMA. This article was originally published online on 8 April 2015 BackgroundIgE mediated cow´s milk allergy (CMA) is a frequent disease in pediatric population, and challenge tests are considered gold standard in its diagnosis, although its use is limited in clinical practice. An appropriated anamnesis and laboratorial analysis are the most frequent and feasible used tools. The aim of this study was to evaluate the role of these practices in IgE mediated CMA diagnosis. IgE mediated cow´s milk allergy (CMA) is a frequent disease in pediatric population, and challenge tests are considered gold standard in its diagnosis, although its use is limited in clinical practice. An appropriated anamnesis and laboratorial analysis are the most frequent and feasible used tools. The aim of this study was to evaluate the role of these practices in IgE mediated CMA diagnosis. MethodsIt was a retrospective study based on patient data charts from a reference center in food allergy. All patients who performed open, single or double blind placebo controlled oral food challenges (OFC) for CMA diagnosis were included. Clinical history was defined as suggestive when patients presented at any time anaphylaxis, urticaria, angioedema, laryngeal edema and dyspnea. Diarrhea, vomiting, cough, wheezing, rhinoconjunctivitis, pruritus and erythema were considered as dubious. Symptoms onset <2 hours after food ingestion was also considered suggestive. Dubious and/or subjective symptoms or delayed ones were considered undetermined. Specific IgE (sIgE) was included when evaluated ± 12 months from OFC. Skin prick test was considered positive when wheal was >3mm and/or serum specific IgE >0.35 kU/L. Sensitivity (Se), specificity (Sp), positive and negative predictive value (PPV and NPV) and likelihood ratio (LR) were established, comparing anamnesis, anaphylaxis, laboratorial tests versus OFC. It was a retrospective study based on patient data charts from a reference center in food allergy. All patients who performed open, single or double blind placebo controlled oral food challenges (OFC) for CMA diagnosis were included. Clinical history was defined as suggestive when patients presented at any time anaphylaxis, urticaria, angioedema, laryngeal edema and dyspnea. Diarrhea, vomiting, cough, wheezing, rhinoconjunctivitis, pruritus and erythema were considered as dubious. Symptoms onset <2 hours after food ingestion was also considered suggestive. Dubious and/or subjective symptoms or delayed ones were considered undetermined. Specific IgE (sIgE) was included when evaluated ± 12 months from OFC. Skin prick test was considered positive when wheal was >3mm and/or serum specific IgE >0.35 kU/L. Sensitivity (Se), specificity (Sp), positive and negative predictive value (PPV and NPV) and likelihood ratio (LR) were established, comparing anamnesis, anaphylaxis, laboratorial tests versus OFC. Results92 patients were included (43 OFC+; 49 OFC-). The median age at challenge test was 2.5 years (0.4-10.7) (OFC+ 3.0y; OFC- 2.4y). The median time between symptoms onset and food challenge was 2.3 years (0.2-10.4) (OFC+ 2.7; OFC- 2.2). Suggestive clinical history was present in 93% of patients in OFC+, compared to 61% of patients in OFC- (Se 93%; Sp 38%; PPV 57%; NPV 86%; LR 1.51; p<0.05). Considering only anaphylactic symptoms versus OFC the results were Se 44%; Sp 87%; PPV 76%; NPV 64% and LR 3.06 (p<0.05). Specific IgE was present in 100% of patients in OFC+ resulting in Se 100%; Sp 48%; PPV 63%; NPV 100% and LR 1.96 (p<0.05). Suggestive clinical history associated with symptoms onset <2 hours and presence of sIgE demonstrated a Se 88%; Sp 73%; PPV 74%; NPV 88% and LR 3.3 (p<0.05). 92 patients were included (43 OFC+; 49 OFC-). The median age at challenge test was 2.5 years (0.4-10.7) (OFC+ 3.0y; OFC- 2.4y). The median time between symptoms onset and food challenge was 2.3 years (0.2-10.4) (OFC+ 2.7; OFC- 2.2). Suggestive clinical history was present in 93% of patients in OFC+, compared to 61% of patients in OFC- (Se 93%; Sp 38%; PPV 57%; NPV 86%; LR 1.51; p<0.05). Considering only anaphylactic symptoms versus OFC the results were Se 44%; Sp 87%; PPV 76%; NPV 64% and LR 3.06 (p<0.05). Specific IgE was present in 100% of patients in OFC+ resulting in Se 100%; Sp 48%; PPV 63%; NPV 100% and LR 1.96 (p<0.05). Suggestive clinical history associated with symptoms onset <2 hours and presence of sIgE demonstrated a Se 88%; Sp 73%; PPV 74%; NPV 88% and LR 3.3 (p<0.05). ConclusionsSuggestive clinical history associated to positive sIgE was helpful on the diagnosis of CMA. Generally, the OFC remains necessary to set or exclude diagnosis. Negative sIgE was useful to exclude CMA. Suggestive clinical history associated to positive sIgE was helpful on the diagnosis of CMA. Generally, the OFC remains necessary to set or exclude diagnosis. Negative sIgE was useful to exclude CMA." @default.
• W1597029785 created "2016-06-24" @default.
• W1597029785 creator A5007331690 @default.
• W1597029785 creator A5056480839 @default.
• W1597029785 creator A5057592645 @default.
• W1597029785 creator A5062818779 @default.
• W1597029785 creator A5063610289 @default.
• W1597029785 creator A5071658380 @default.
• W1597029785 creator A5072937287 @default.
• W1597029785 creator A5076123687 @default.
• W1597029785 creator A5078622870 @default.
• W1597029785 date "2015-01-01" @default.
• W1597029785 modified "2023-10-08" @default.
• W1597029785 title "Evaluating the role of clinical history and laboratorial tests in IgE mediated cow's milk allergy diagnosis" @default.
• W1597029785 doi "https://doi.org/10.1186/1939-4551-8-s1-a124" @default.
• W1597029785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4406205" @default.
• W1597029785 hasPublicationYear "2015" @default.
• W1597029785 type Work @default.
• W1597029785 sameAs 1597029785 @default.
• W1597029785 citedByCount "0" @default.
• W1597029785 crossrefType "journal-article" @default.
• W1597029785 hasAuthorship W1597029785A5007331690 @default.
• W1597029785 hasAuthorship W1597029785A5056480839 @default.
• W1597029785 hasAuthorship W1597029785A5057592645 @default.
• W1597029785 hasAuthorship W1597029785A5062818779 @default.
• W1597029785 hasAuthorship W1597029785A5063610289 @default.
• W1597029785 hasAuthorship W1597029785A5071658380 @default.
• W1597029785 hasAuthorship W1597029785A5072937287 @default.
• W1597029785 hasAuthorship W1597029785A5076123687 @default.
• W1597029785 hasAuthorship W1597029785A5078622870 @default.
• W1597029785 hasBestOaLocation W15970297851 @default.
• W1597029785 hasConcept C126322002 @default.
• W1597029785 hasConcept C141105273 @default.
• W1597029785 hasConcept C159654299 @default.
• W1597029785 hasConcept C185592680 @default.
• W1597029785 hasConcept C203014093 @default.
• W1597029785 hasConcept C207480886 @default.
• W1597029785 hasConcept C2776027960 @default.
• W1597029785 hasConcept C2781372412 @default.
• W1597029785 hasConcept C2909917878 @default.
• W1597029785 hasConcept C2992897362 @default.
• W1597029785 hasConcept C2992972311 @default.
• W1597029785 hasConcept C31903555 @default.
• W1597029785 hasConcept C71924100 @default.
• W1597029785 hasConceptScore W1597029785C126322002 @default.
• W1597029785 hasConceptScore W1597029785C141105273 @default.
• W1597029785 hasConceptScore W1597029785C159654299 @default.
• W1597029785 hasConceptScore W1597029785C185592680 @default.
• W1597029785 hasConceptScore W1597029785C203014093 @default.
• W1597029785 hasConceptScore W1597029785C207480886 @default.
• W1597029785 hasConceptScore W1597029785C2776027960 @default.
• W1597029785 hasConceptScore W1597029785C2781372412 @default.
• W1597029785 hasConceptScore W1597029785C2909917878 @default.
• W1597029785 hasConceptScore W1597029785C2992897362 @default.
• W1597029785 hasConceptScore W1597029785C2992972311 @default.
• W1597029785 hasConceptScore W1597029785C31903555 @default.
• W1597029785 hasConceptScore W1597029785C71924100 @default.
• W1597029785 hasLocation W15970297851 @default.
• W1597029785 hasLocation W15970297852 @default.
• W1597029785 hasLocation W15970297853 @default.
• W1597029785 hasOpenAccess W1597029785 @default.
• W1597029785 hasPrimaryLocation W15970297851 @default.
• W1597029785 hasRelatedWork W1868475069 @default.
• W1597029785 hasRelatedWork W2017616799 @default.
• W1597029785 hasRelatedWork W2054023981 @default.
• W1597029785 hasRelatedWork W2057540370 @default.
• W1597029785 hasRelatedWork W2077330663 @default.
• W1597029785 hasRelatedWork W2097363323 @default.
• W1597029785 hasRelatedWork W2116755419 @default.
• W1597029785 hasRelatedWork W2119696715 @default.
• W1597029785 hasRelatedWork W2784104601 @default.
• W1597029785 hasRelatedWork W4306409849 @default.
• W1597029785 hasVolume "8" @default.
• W1597029785 isParatext "false" @default.
• W1597029785 isRetracted "false" @default.
• W1597029785 magId "1597029785" @default.
• W1597029785 workType "article" @default.