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• W1597054100 abstract "The unc-47 locus of Caenorhabditis elegans has been suggested to encode a synaptic vesicle GABA transporter. Here we used hydropathy plot analysis to identify a candidate vesicular GABA transporter in genomic sequences derived from a region of the physical map comprising unc-47. A mouse homologue was identified and cloned from EST database information. In situ hybridization in rat brain revealed codistribution with both GABAergic and glycinergic neuronal markers. Moreover, expression in COS-7 and PC12 cells induced an intracellular, glycine-sensitive GABA uptake activity. These observations, consistent with previous data on GABA and glycine uptake by synaptic vesicles, demonstrate that the mouse clone encodes a vesicular inhibitory amino acid transporter." @default.
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• W1597054100 date "1997-11-10" @default.
• W1597054100 modified "2023-10-15" @default.
• W1597054100 title "Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases" @default.
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• W1597054100 doi "https://doi.org/10.1016/s0014-5793(97)01279-9" @default.
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