FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597247403> ?p ?o ?g. }

• W1597247403 endingPage "705" @default.
• W1597247403 startingPage "696" @default.
• W1597247403 abstract "To examine the retinotoxic effect of naphthalene, a powerful oxidative agent and a well-known cataractogenic agent.A 10% solution of naphthalene dissolved in paraffin oil was given every other day by gavage to 31 pigmented rabbits for 5 weeks, at a dose of 1 g/kg body weight. Four rabbits who received only paraffin oil served as controls. The eyes were clinically followed up by means of ophthalmoscopy and retinal fluorangiography. At selected intervals, the eyes were examined with light microscopy and transmission electron microscopy.The first lesions were focal and appeared in the periphery of the fundus about 3 weeks after the beginning of treatment and tended to spread over the entire retina. Histologically, there was a degeneration of photoreceptors, accompanied by a reaction and proliferation of retinal pigment epithelium (RPE) that phagocytized the damaged visual cells. After about 3 months, the proliferation of RPE was followed by subretinal neovascularization (SRN). Both mature fenestrated and thick-walled non-fenestrated capillaries penetrated Bruch's membrane, enveloped by abundant fibrous extracellular matrix and accompanied by pericytes. As a consequence of this process, the retina was focally transformed into a neovascular complex in which a vascular plexus was intermingled with pseudo-acinar cavities lined by RPE. There were no signs of SRN at retinal fluorangiography, possibly because of the dense microenvironment of extracellular matrix and RPE cells of the neovascular complexes.Naphthalene degeneration of the rabbit retina appears to be a simple model of photoreceptor vulnerability in the first stages of SRN thereafter. The close chronologic and topographic relationship between the appearance of the anomalous vessels and RPE alteration and the close resemblance with previous models of experimental SRN may support the hypothesis of an experimental model of SRN triggered by the RPE." @default.
• W1597247403 created "2016-06-24" @default.
• W1597247403 creator A5043703940 @default.
• W1597247403 creator A5044828180 @default.
• W1597247403 creator A5075765758 @default.
• W1597247403 date "1994-02-01" @default.
• W1597247403 modified "2023-09-23" @default.
• W1597247403 title "Subretinal neovascularization after naphthalene damage to the rabbit retina." @default.
• W1597247403 cites W147502263 @default.
• W1597247403 cites W1590165801 @default.
• W1597247403 cites W165951800 @default.
• W1597247403 cites W183491882 @default.
• W1597247403 cites W1974904098 @default.
• W1597247403 cites W1975107877 @default.
• W1597247403 cites W198537089 @default.
• W1597247403 cites W2003537037 @default.
• W1597247403 cites W2016978125 @default.
• W1597247403 cites W2020715675 @default.
• W1597247403 cites W2023001893 @default.
• W1597247403 cites W2037646512 @default.
• W1597247403 cites W2038914274 @default.
• W1597247403 cites W2040140021 @default.
• W1597247403 cites W2042081001 @default.
• W1597247403 cites W2044650785 @default.
• W1597247403 cites W2046908090 @default.
• W1597247403 cites W2057180636 @default.
• W1597247403 cites W2060114316 @default.
• W1597247403 cites W2062703434 @default.
• W1597247403 cites W2075845352 @default.
• W1597247403 cites W2082902429 @default.
• W1597247403 cites W2122295248 @default.
• W1597247403 cites W2161338594 @default.
• W1597247403 cites W2268324951 @default.
• W1597247403 cites W17299339 @default.
• W1597247403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8113020" @default.
• W1597247403 hasPublicationYear "1994" @default.
• W1597247403 type Work @default.
• W1597247403 sameAs 1597247403 @default.
• W1597247403 citedByCount "11" @default.
• W1597247403 countsByYear W15972474032016 @default.
• W1597247403 countsByYear W15972474032021 @default.
• W1597247403 crossrefType "journal-article" @default.
• W1597247403 hasAuthorship W1597247403A5043703940 @default.
• W1597247403 hasAuthorship W1597247403A5044828180 @default.
• W1597247403 hasAuthorship W1597247403A5075765758 @default.
• W1597247403 hasConcept C105702510 @default.
• W1597247403 hasConcept C118487528 @default.
• W1597247403 hasConcept C142724271 @default.
• W1597247403 hasConcept C169760540 @default.
• W1597247403 hasConcept C185592680 @default.
• W1597247403 hasConcept C189165786 @default.
• W1597247403 hasConcept C2776391266 @default.
• W1597247403 hasConcept C2776403814 @default.
• W1597247403 hasConcept C2776694393 @default.
• W1597247403 hasConcept C2777093970 @default.
• W1597247403 hasConcept C2778024200 @default.
• W1597247403 hasConcept C2778271429 @default.
• W1597247403 hasConcept C2780394083 @default.
• W1597247403 hasConcept C2780827179 @default.
• W1597247403 hasConcept C2781359195 @default.
• W1597247403 hasConcept C502942594 @default.
• W1597247403 hasConcept C55493867 @default.
• W1597247403 hasConcept C71924100 @default.
• W1597247403 hasConcept C86803240 @default.
• W1597247403 hasConcept C95444343 @default.
• W1597247403 hasConceptScore W1597247403C105702510 @default.
• W1597247403 hasConceptScore W1597247403C118487528 @default.
• W1597247403 hasConceptScore W1597247403C142724271 @default.
• W1597247403 hasConceptScore W1597247403C169760540 @default.
• W1597247403 hasConceptScore W1597247403C185592680 @default.
• W1597247403 hasConceptScore W1597247403C189165786 @default.
• W1597247403 hasConceptScore W1597247403C2776391266 @default.
• W1597247403 hasConceptScore W1597247403C2776403814 @default.
• W1597247403 hasConceptScore W1597247403C2776694393 @default.
• W1597247403 hasConceptScore W1597247403C2777093970 @default.
• W1597247403 hasConceptScore W1597247403C2778024200 @default.
• W1597247403 hasConceptScore W1597247403C2778271429 @default.
• W1597247403 hasConceptScore W1597247403C2780394083 @default.
• W1597247403 hasConceptScore W1597247403C2780827179 @default.
• W1597247403 hasConceptScore W1597247403C2781359195 @default.
• W1597247403 hasConceptScore W1597247403C502942594 @default.
• W1597247403 hasConceptScore W1597247403C55493867 @default.
• W1597247403 hasConceptScore W1597247403C71924100 @default.
• W1597247403 hasConceptScore W1597247403C86803240 @default.
• W1597247403 hasConceptScore W1597247403C95444343 @default.
• W1597247403 hasIssue "2" @default.
• W1597247403 hasLocation W15972474031 @default.
• W1597247403 hasOpenAccess W1597247403 @default.
• W1597247403 hasPrimaryLocation W15972474031 @default.
• W1597247403 hasRelatedWork W1968289616 @default.
• W1597247403 hasRelatedWork W1998386860 @default.
• W1597247403 hasRelatedWork W2011396135 @default.
• W1597247403 hasRelatedWork W2033072335 @default.
• W1597247403 hasRelatedWork W2033815041 @default.
• W1597247403 hasRelatedWork W2040829413 @default.
• W1597247403 hasRelatedWork W2161400914 @default.
• W1597247403 hasRelatedWork W2324141446 @default.
• W1597247403 hasRelatedWork W2785954970 @default.

• next