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• W1597268540 abstract "Bispecific antibodies are molecules capable of simultaneously binding to two different antigens. While initially bispecific antibodies have been developed mainly for cellular cancer immunotherapy through retargeting of effector cells to tumor cells, recent developments include also dual targeting strategies and the retargeting of effector molecules, e.g. in radioimmunotherapy. In addition to various applications, a plethora of bispecific antibody formats have been developed, including small recombinant bispecific molecules comprising only the variable domains of two antibodies and tetravalent IgG-like bispecific antibodies. In this chapter we will focus on the most relevant bispecific antibody formats, explaining the therapeutic concepts, the methodology involved in their production and the preclinical and clinical achievements, so far." @default.
• W1597268540 created "2016-06-24" @default.
• W1597268540 creator A5083116292 @default.
• W1597268540 date "2011-01-01" @default.
• W1597268540 modified "2023-10-06" @default.
• W1597268540 title "Recombinant Bispecific Antibodies for Cancer Therapy" @default.
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• W1597268540 doi "https://doi.org/10.1007/978-94-007-1257-7_11" @default.
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