FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597314866> ?p ?o ?g. }

• W1597314866 endingPage "1399" @default.
• W1597314866 startingPage "1393" @default.
• W1597314866 abstract "Proinflammatory cytokines may sensitize primary sensory neurons and facilitate development of neuropathic pain processes after peripheral nerve injury. The goal of this study was to determine whether responses of dorsal root ganglion (DRG) neurons to exogenous tumor necrosis factor alpha (TNF-alpha) are altered in a chronically compressed DRG (CCD) injury model. Extracellular recordings from teased dorsal root microfilaments demonstrated that acute topical application of TNF-alpha to the DRG for 15 min evoked C- and Abeta-fiber responses in both normal and CCD rats. However, the response latency was significantly shorter, and the peak discharge rate was higher, in CCD fibers than in normal fibers. Intracellular recordings from small- and large-sized neurons showed that TNF-alpha induced greater depolarization and greater decrease in rheobase in CCD neurons than in normal neurons. The proportion of both small- and large-sized neurons that were responsive to TNF-alpha increased significantly after CCD injury. Furthermore, TNF-alpha altered the discharge patterns of large, spontaneously active neurons in addition to enhancing their discharge rates. However, the depolarization caused by TNF-alpha in such neurons was minor (<2 mV). Inflammatory cytokines such as TNF-alpha increased the sensitivity of sensory neurons in normal and CCD rats. The CCD injury itself, on the other hand, increased neuronal responses to inflammatory cytokines." @default.
• W1597314866 created "2016-06-24" @default.
• W1597314866 creator A5003096187 @default.
• W1597314866 creator A5014506158 @default.
• W1597314866 creator A5031293472 @default.
• W1597314866 creator A5039110409 @default.
• W1597314866 date "2002-09-01" @default.
• W1597314866 modified "2023-10-15" @default.
• W1597314866 title "Increased Sensitivity of Sensory Neurons to Tumor Necrosis Factor α in Rats With Chronic Compression of the Lumbar Ganglia" @default.
• W1597314866 cites W1816134939 @default.
• W1597314866 cites W1818085992 @default.
• W1597314866 cites W1873187871 @default.
• W1597314866 cites W1964497912 @default.
• W1597314866 cites W1975220342 @default.
• W1597314866 cites W1975298116 @default.
• W1597314866 cites W1975948400 @default.
• W1597314866 cites W1978130724 @default.
• W1597314866 cites W1981014302 @default.
• W1597314866 cites W1984632338 @default.
• W1597314866 cites W1991424097 @default.
• W1597314866 cites W1994392334 @default.
• W1597314866 cites W2001699192 @default.
• W1597314866 cites W2003097388 @default.
• W1597314866 cites W2012359641 @default.
• W1597314866 cites W2012944381 @default.
• W1597314866 cites W2013906894 @default.
• W1597314866 cites W2016735320 @default.
• W1597314866 cites W2024941342 @default.
• W1597314866 cites W2029227926 @default.
• W1597314866 cites W2048883652 @default.
• W1597314866 cites W2058284000 @default.
• W1597314866 cites W2060072971 @default.
• W1597314866 cites W2078799084 @default.
• W1597314866 cites W2083451318 @default.
• W1597314866 cites W2088189953 @default.
• W1597314866 cites W2118681496 @default.
• W1597314866 cites W377849966 @default.
• W1597314866 cites W4242579697 @default.
• W1597314866 cites W4313635400 @default.
• W1597314866 doi "https://doi.org/10.1152/jn.2002.88.3.1393" @default.
• W1597314866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12205160" @default.
• W1597314866 hasPublicationYear "2002" @default.
• W1597314866 type Work @default.
• W1597314866 sameAs 1597314866 @default.
• W1597314866 citedByCount "84" @default.
• W1597314866 countsByYear W15973148662012 @default.
• W1597314866 countsByYear W15973148662013 @default.
• W1597314866 countsByYear W15973148662014 @default.
• W1597314866 countsByYear W15973148662015 @default.
• W1597314866 countsByYear W15973148662016 @default.
• W1597314866 countsByYear W15973148662018 @default.
• W1597314866 countsByYear W15973148662019 @default.
• W1597314866 countsByYear W15973148662021 @default.
• W1597314866 countsByYear W15973148662022 @default.
• W1597314866 countsByYear W15973148662023 @default.
• W1597314866 crossrefType "journal-article" @default.
• W1597314866 hasAuthorship W1597314866A5003096187 @default.
• W1597314866 hasAuthorship W1597314866A5014506158 @default.
• W1597314866 hasAuthorship W1597314866A5031293472 @default.
• W1597314866 hasAuthorship W1597314866A5039110409 @default.
• W1597314866 hasConcept C126322002 @default.
• W1597314866 hasConcept C134018914 @default.
• W1597314866 hasConcept C15490471 @default.
• W1597314866 hasConcept C164027704 @default.
• W1597314866 hasConcept C169760540 @default.
• W1597314866 hasConcept C170493617 @default.
• W1597314866 hasConcept C172659308 @default.
• W1597314866 hasConcept C17991360 @default.
• W1597314866 hasConcept C2775908076 @default.
• W1597314866 hasConcept C2775991916 @default.
• W1597314866 hasConcept C2776281502 @default.
• W1597314866 hasConcept C2776880756 @default.
• W1597314866 hasConcept C2776914184 @default.
• W1597314866 hasConcept C2777107010 @default.
• W1597314866 hasConcept C2781149210 @default.
• W1597314866 hasConcept C4141045 @default.
• W1597314866 hasConcept C71924100 @default.
• W1597314866 hasConcept C77231231 @default.
• W1597314866 hasConcept C86803240 @default.
• W1597314866 hasConcept C94487597 @default.
• W1597314866 hasConceptScore W1597314866C126322002 @default.
• W1597314866 hasConceptScore W1597314866C134018914 @default.
• W1597314866 hasConceptScore W1597314866C15490471 @default.
• W1597314866 hasConceptScore W1597314866C164027704 @default.
• W1597314866 hasConceptScore W1597314866C169760540 @default.
• W1597314866 hasConceptScore W1597314866C170493617 @default.
• W1597314866 hasConceptScore W1597314866C172659308 @default.
• W1597314866 hasConceptScore W1597314866C17991360 @default.
• W1597314866 hasConceptScore W1597314866C2775908076 @default.
• W1597314866 hasConceptScore W1597314866C2775991916 @default.
• W1597314866 hasConceptScore W1597314866C2776281502 @default.
• W1597314866 hasConceptScore W1597314866C2776880756 @default.
• W1597314866 hasConceptScore W1597314866C2776914184 @default.
• W1597314866 hasConceptScore W1597314866C2777107010 @default.
• W1597314866 hasConceptScore W1597314866C2781149210 @default.
• W1597314866 hasConceptScore W1597314866C4141045 @default.
• W1597314866 hasConceptScore W1597314866C71924100 @default.
• W1597314866 hasConceptScore W1597314866C77231231 @default.

• next