FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597331818> ?p ?o ?g. }

• W1597331818 endingPage "6688" @default.
• W1597331818 startingPage "6682" @default.
• W1597331818 abstract "The simian virus 40 large T antigen is a promiscuous transcriptional activator of many viral and cellular promoters. We show that the promoter structure necessary for T antigen-mediated transcriptional activation is very simple. A TATA or initiator element is required, in addition to an upstream factor-binding site, which can be quite variable. We found that promoters containing an SP1-, ATF-, AP1-, or TEF-I-binding site, in conjunction with a TATA element, can all be activated in the presence of T antigen. In addition, preference for specific TATA elements was indicated. Promoters containing the HSP70 TATA element functioned better than those with the adenovirus E2 TATA element, while promoters containing the simian virus 40 (SV40) early TATA element failed to be activated. In addition, simple promoters containing the initiator element from the terminal deoxynucleotidyltransferase gene could be activated by T antigen. The SV40 late promoter, a primary target for T antigen transcriptional activation, conforms to this simple promoter structure. The region from which most late transcripts initiate contains a cluster of initiator-like elements (SV40 nucleotides [nt] 250 to 335) forming an initiator region (IR). This lies downstream of the previously described octamer-TEF element (SV40 nt 199 to 218) which contains the TEF-I-binding sites shown to be necessary for T antigen-mediated transcriptional activation of the late promoter. We show that a simple late promoter made up of IR sequences and octamer-TEF element-containing sequences is transcriptionally activated by T antigen. These experiments also showed that specific sequences in the IR, SV40 nt 272 to 294, are particularly important for late promoter activation. Previous findings (M. C. Gruda, J. M. Zablotny, J. H. Xiao, I. Davidson, and J. C. Alwine, Mol. Cell. Biol. 13:961-969, 1993) suggested that T antigen could mediate transcriptional activation through interaction with the TATA-binding protein, as well as upstream bound transcription factors. Our present data are predicted by this model and suggest that at least one mechanism by which the T antigen manifests promiscuous transcriptional activation is its ability to interact with numerous transcription factors in a simple promoter context." @default.
• W1597331818 created "2016-06-24" @default.
• W1597331818 creator A5050104363 @default.
• W1597331818 creator A5080729907 @default.
• W1597331818 date "1993-11-01" @default.
• W1597331818 modified "2023-09-26" @default.
• W1597331818 title "Transcriptional activation by simian virus 40 large T antigen: requirements for simple promoter structures containing either TATA or initiator elements with variable upstream factor binding sites" @default.
• W1597331818 cites W109204618 @default.
• W1597331818 cites W1534298859 @default.
• W1597331818 cites W1574526610 @default.
• W1597331818 cites W1687511301 @default.
• W1597331818 cites W1715424350 @default.
• W1597331818 cites W1771303107 @default.
• W1597331818 cites W1806844342 @default.
• W1597331818 cites W1836420458 @default.
• W1597331818 cites W1853604224 @default.
• W1597331818 cites W1870745239 @default.
• W1597331818 cites W1905356657 @default.
• W1597331818 cites W1906159205 @default.
• W1597331818 cites W1944116599 @default.
• W1597331818 cites W1946398925 @default.
• W1597331818 cites W1954929088 @default.
• W1597331818 cites W1971458294 @default.
• W1597331818 cites W1999156595 @default.
• W1597331818 cites W2018433232 @default.
• W1597331818 cites W2027216583 @default.
• W1597331818 cites W2029065830 @default.
• W1597331818 cites W2049621422 @default.
• W1597331818 cites W205747925 @default.
• W1597331818 cites W2060017591 @default.
• W1597331818 cites W2084186257 @default.
• W1597331818 cites W2089443802 @default.
• W1597331818 cites W2096367521 @default.
• W1597331818 cites W2126709970 @default.
• W1597331818 cites W2132693026 @default.
• W1597331818 cites W2134078619 @default.
• W1597331818 cites W2144206181 @default.
• W1597331818 cites W2147224696 @default.
• W1597331818 cites W2148665498 @default.
• W1597331818 cites W2415789938 @default.
• W1597331818 doi "https://doi.org/10.1128/jvi.67.11.6682-6688.1993" @default.
• W1597331818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/238107" @default.
• W1597331818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8411370" @default.
• W1597331818 hasPublicationYear "1993" @default.
• W1597331818 type Work @default.
• W1597331818 sameAs 1597331818 @default.
• W1597331818 citedByCount "44" @default.
• W1597331818 countsByYear W15973318182014 @default.
• W1597331818 countsByYear W15973318182017 @default.
• W1597331818 countsByYear W15973318182020 @default.
• W1597331818 countsByYear W15973318182021 @default.
• W1597331818 crossrefType "journal-article" @default.
• W1597331818 hasAuthorship W1597331818A5050104363 @default.
• W1597331818 hasAuthorship W1597331818A5080729907 @default.
• W1597331818 hasBestOaLocation W15973318181 @default.
• W1597331818 hasConcept C101762097 @default.
• W1597331818 hasConcept C104317684 @default.
• W1597331818 hasConcept C132376346 @default.
• W1597331818 hasConcept C138885662 @default.
• W1597331818 hasConcept C150194340 @default.
• W1597331818 hasConcept C153911025 @default.
• W1597331818 hasConcept C173681060 @default.
• W1597331818 hasConcept C179926584 @default.
• W1597331818 hasConcept C41895202 @default.
• W1597331818 hasConcept C54355233 @default.
• W1597331818 hasConcept C64927066 @default.
• W1597331818 hasConcept C65888428 @default.
• W1597331818 hasConcept C84772758 @default.
• W1597331818 hasConcept C86803240 @default.
• W1597331818 hasConceptScore W1597331818C101762097 @default.
• W1597331818 hasConceptScore W1597331818C104317684 @default.
• W1597331818 hasConceptScore W1597331818C132376346 @default.
• W1597331818 hasConceptScore W1597331818C138885662 @default.
• W1597331818 hasConceptScore W1597331818C150194340 @default.
• W1597331818 hasConceptScore W1597331818C153911025 @default.
• W1597331818 hasConceptScore W1597331818C173681060 @default.
• W1597331818 hasConceptScore W1597331818C179926584 @default.
• W1597331818 hasConceptScore W1597331818C41895202 @default.
• W1597331818 hasConceptScore W1597331818C54355233 @default.
• W1597331818 hasConceptScore W1597331818C64927066 @default.
• W1597331818 hasConceptScore W1597331818C65888428 @default.
• W1597331818 hasConceptScore W1597331818C84772758 @default.
• W1597331818 hasConceptScore W1597331818C86803240 @default.
• W1597331818 hasIssue "11" @default.
• W1597331818 hasLocation W15973318181 @default.
• W1597331818 hasLocation W15973318182 @default.
• W1597331818 hasLocation W15973318183 @default.
• W1597331818 hasLocation W15973318184 @default.
• W1597331818 hasOpenAccess W1597331818 @default.
• W1597331818 hasPrimaryLocation W15973318181 @default.
• W1597331818 hasRelatedWork W1588860880 @default.
• W1597331818 hasRelatedWork W1852931409 @default.
• W1597331818 hasRelatedWork W1971069125 @default.
• W1597331818 hasRelatedWork W2034384738 @default.
• W1597331818 hasRelatedWork W2101898 @default.
• W1597331818 hasRelatedWork W2146975493 @default.
• W1597331818 hasRelatedWork W2179812999 @default.
• W1597331818 hasRelatedWork W2243471728 @default.

• next