Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597333775> ?p ?o ?g. }
- W1597333775 endingPage "354" @default.
- W1597333775 startingPage "337" @default.
- W1597333775 abstract "Proliferation of epithelial tissues is controlled by polarized distribution of signaling receptors including the EGF receptor (EGFR). In kidney, EGFRs are segregated from soluble ligands present in apical fluid of nephrons by selective targeting to basolateral membranes. We have shown previously that the epithelial-specific clathrin adaptor AP1B mediates basolateral EGFR sorting in established epithelia. Here we show that protein kinase C (PKC)-dependent phosphorylation of Thr654 regulates EGFR polarity as epithelial cells form new cell-cell junctional complexes. The AP1B-dependent pathway does not override a PKC-resistant T654A mutation, and conversely AP1B-defective EGFRs sort basolaterally by a PKC-dependent mechanism, in polarizing cells. Surprisingly, EGFR mutations that interfere with these different sorting pathways also produce very distinct phenotypes in three-dimensional organotypic cultures. Thus EGFRs execute different functions depending on the basolateral sorting route. Many renal disorders have defects in cell polarity and the notion that apically mislocalized EGFRs promote proliferation is still an attractive model to explain many aspects of polycystic kidney disease. Our data suggest EGFR also integrates various aspects of polarity by switching between different basolateral sorting programs in developing epithelial cells. Fundamental knowledge of basic mechanisms governing EGFR sorting therefore provides new insights into pathogenesis and advances drug discovery for these renal disorders." @default.
- W1597333775 created "2016-06-24" @default.
- W1597333775 creator A5022344420 @default.
- W1597333775 creator A5026735416 @default.
- W1597333775 creator A5027007744 @default.
- W1597333775 creator A5065080692 @default.
- W1597333775 date "2012-12-28" @default.
- W1597333775 modified "2023-09-27" @default.
- W1597333775 title "Basolateral EGF Receptor Sorting Regulated by Functionally Distinct Mechanisms in Renal Epithelial Cells" @default.
- W1597333775 cites W1529934239 @default.
- W1597333775 cites W1958172963 @default.
- W1597333775 cites W1966041595 @default.
- W1597333775 cites W1967737783 @default.
- W1597333775 cites W1968013329 @default.
- W1597333775 cites W1972977050 @default.
- W1597333775 cites W1976094538 @default.
- W1597333775 cites W1982558555 @default.
- W1597333775 cites W1982584353 @default.
- W1597333775 cites W1986096022 @default.
- W1597333775 cites W1989945871 @default.
- W1597333775 cites W1991379362 @default.
- W1597333775 cites W1992557926 @default.
- W1597333775 cites W1995337883 @default.
- W1597333775 cites W2002273560 @default.
- W1597333775 cites W2003649795 @default.
- W1597333775 cites W2004315072 @default.
- W1597333775 cites W2005938853 @default.
- W1597333775 cites W2008758305 @default.
- W1597333775 cites W2010621903 @default.
- W1597333775 cites W2012507368 @default.
- W1597333775 cites W2014038941 @default.
- W1597333775 cites W2016684852 @default.
- W1597333775 cites W2021680131 @default.
- W1597333775 cites W2025791117 @default.
- W1597333775 cites W2026549297 @default.
- W1597333775 cites W2028811272 @default.
- W1597333775 cites W2031325295 @default.
- W1597333775 cites W2034271898 @default.
- W1597333775 cites W2034975029 @default.
- W1597333775 cites W2039156965 @default.
- W1597333775 cites W2041660771 @default.
- W1597333775 cites W2044749599 @default.
- W1597333775 cites W2048616064 @default.
- W1597333775 cites W2053958751 @default.
- W1597333775 cites W2056535053 @default.
- W1597333775 cites W2057733044 @default.
- W1597333775 cites W2062835218 @default.
- W1597333775 cites W2062922218 @default.
- W1597333775 cites W2062976091 @default.
- W1597333775 cites W2067376187 @default.
- W1597333775 cites W2069120227 @default.
- W1597333775 cites W2069354876 @default.
- W1597333775 cites W2070947895 @default.
- W1597333775 cites W2073291237 @default.
- W1597333775 cites W2076372741 @default.
- W1597333775 cites W2079572256 @default.
- W1597333775 cites W2082861222 @default.
- W1597333775 cites W2085344344 @default.
- W1597333775 cites W2086341057 @default.
- W1597333775 cites W2099025954 @default.
- W1597333775 cites W2099936921 @default.
- W1597333775 cites W2100522469 @default.
- W1597333775 cites W2105278153 @default.
- W1597333775 cites W2107292352 @default.
- W1597333775 cites W2109844668 @default.
- W1597333775 cites W2114594837 @default.
- W1597333775 cites W2118613141 @default.
- W1597333775 cites W2123153844 @default.
- W1597333775 cites W2126582065 @default.
- W1597333775 cites W2133802070 @default.
- W1597333775 cites W2134973422 @default.
- W1597333775 cites W2137261534 @default.
- W1597333775 cites W2143984541 @default.
- W1597333775 cites W2145410464 @default.
- W1597333775 cites W2151352552 @default.
- W1597333775 cites W2182978714 @default.
- W1597333775 cites W2204738624 @default.
- W1597333775 cites W2298026931 @default.
- W1597333775 cites W2315102722 @default.
- W1597333775 cites W2419009088 @default.
- W1597333775 cites W3140604265 @default.
- W1597333775 cites W4254063383 @default.
- W1597333775 doi "https://doi.org/10.1111/tra.12032" @default.
- W1597333775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4304763" @default.
- W1597333775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23205726" @default.
- W1597333775 hasPublicationYear "2012" @default.
- W1597333775 type Work @default.
- W1597333775 sameAs 1597333775 @default.
- W1597333775 citedByCount "13" @default.
- W1597333775 countsByYear W15973337752013 @default.
- W1597333775 countsByYear W15973337752014 @default.
- W1597333775 countsByYear W15973337752015 @default.
- W1597333775 countsByYear W15973337752017 @default.
- W1597333775 countsByYear W15973337752018 @default.
- W1597333775 countsByYear W15973337752019 @default.
- W1597333775 countsByYear W15973337752020 @default.
- W1597333775 crossrefType "journal-article" @default.
- W1597333775 hasAuthorship W1597333775A5022344420 @default.