Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597434077> ?p ?o ?g. }
- W1597434077 endingPage "5" @default.
- W1597434077 startingPage "1" @default.
- W1597434077 abstract "Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid that have been used to reduce the incidence, growth and metastasis of breast, colon, prostate and gastric cancer in animals. CLA could reduce tumor growth by altering angiogenesis; a process requiring associated angiogenic factors such as vascular endothelial growth factor (VEGF). In this study, we determined whether CLA could modulate the expression of VEGF in murine mammary tumor cells and adipocytes. The c9, t11-CLA isomer reduced VEGF transcripts and protein when mammary tumor cells were stimulated with PMA. That isomer also reduced VEGF expression in unstimulated mouse 3T3-L1 adipocytes. Since VEGF can be regulated by cyclooxygenase-2 (COX-2), we determined whether CLA could alter COX-2 enzyme expression and PGE₂ production. The c9, t11-CLA isomer reduced not only COX-2 enzyme expression but also PGE₂ production. Thus, c9, t11-CLA could modulate neovascularization by alteration of VEGF expression from mammary tumor cells and adipocytes by reducing COX-2 metabolites." @default.
- W1597434077 created "2016-06-24" @default.
- W1597434077 creator A5020282158 @default.
- W1597434077 creator A5040148362 @default.
- W1597434077 creator A5062355226 @default.
- W1597434077 creator A5063889306 @default.
- W1597434077 date "2006-03-01" @default.
- W1597434077 modified "2023-10-14" @default.
- W1597434077 title "Conjugated Linoleic Acid Reduction of Vascular Endothelial Growth Factor Expression in Murine Mammary Tumor Cells through Alteration of Prostaglandin E2" @default.
- W1597434077 cites W1575136721 @default.
- W1597434077 cites W1606991007 @default.
- W1597434077 cites W1972385110 @default.
- W1597434077 cites W1973720695 @default.
- W1597434077 cites W1977638852 @default.
- W1597434077 cites W1980425117 @default.
- W1597434077 cites W1983763042 @default.
- W1597434077 cites W1984921618 @default.
- W1597434077 cites W1999323686 @default.
- W1597434077 cites W1999840130 @default.
- W1597434077 cites W2001212320 @default.
- W1597434077 cites W2003584977 @default.
- W1597434077 cites W2006722126 @default.
- W1597434077 cites W2010335828 @default.
- W1597434077 cites W2010959160 @default.
- W1597434077 cites W2013418062 @default.
- W1597434077 cites W2023053806 @default.
- W1597434077 cites W2026382357 @default.
- W1597434077 cites W2030979921 @default.
- W1597434077 cites W2039687540 @default.
- W1597434077 cites W2042401931 @default.
- W1597434077 cites W2042728398 @default.
- W1597434077 cites W2045358575 @default.
- W1597434077 cites W2047460835 @default.
- W1597434077 cites W2054066890 @default.
- W1597434077 cites W2056636411 @default.
- W1597434077 cites W2058026824 @default.
- W1597434077 cites W2058528752 @default.
- W1597434077 cites W2064143393 @default.
- W1597434077 cites W2064682906 @default.
- W1597434077 cites W2065765195 @default.
- W1597434077 cites W2065852951 @default.
- W1597434077 cites W2076156821 @default.
- W1597434077 cites W2082546747 @default.
- W1597434077 cites W2083755003 @default.
- W1597434077 cites W2084018568 @default.
- W1597434077 cites W2086980182 @default.
- W1597434077 cites W2087579464 @default.
- W1597434077 cites W2093096023 @default.
- W1597434077 cites W2094495216 @default.
- W1597434077 cites W2094768791 @default.
- W1597434077 cites W2096385342 @default.
- W1597434077 cites W2096709486 @default.
- W1597434077 cites W2115421884 @default.
- W1597434077 cites W2116228760 @default.
- W1597434077 cites W2118855413 @default.
- W1597434077 cites W2122583090 @default.
- W1597434077 cites W2141881913 @default.
- W1597434077 cites W2142161977 @default.
- W1597434077 cites W2153268591 @default.
- W1597434077 cites W2161784772 @default.
- W1597434077 cites W2162011232 @default.
- W1597434077 cites W2167549919 @default.
- W1597434077 cites W2170507464 @default.
- W1597434077 cites W2171005136 @default.
- W1597434077 cites W2345502648 @default.
- W1597434077 doi "https://doi.org/10.3746/jfn.2006.11.1.001" @default.
- W1597434077 hasPublicationYear "2006" @default.
- W1597434077 type Work @default.
- W1597434077 sameAs 1597434077 @default.
- W1597434077 citedByCount "6" @default.
- W1597434077 crossrefType "journal-article" @default.
- W1597434077 hasAuthorship W1597434077A5020282158 @default.
- W1597434077 hasAuthorship W1597434077A5040148362 @default.
- W1597434077 hasAuthorship W1597434077A5062355226 @default.
- W1597434077 hasAuthorship W1597434077A5063889306 @default.
- W1597434077 hasConcept C121608353 @default.
- W1597434077 hasConcept C126322002 @default.
- W1597434077 hasConcept C134018914 @default.
- W1597434077 hasConcept C167734588 @default.
- W1597434077 hasConcept C185592680 @default.
- W1597434077 hasConcept C2776187077 @default.
- W1597434077 hasConcept C2777025900 @default.
- W1597434077 hasConcept C2777198256 @default.
- W1597434077 hasConcept C2777956040 @default.
- W1597434077 hasConcept C2778271429 @default.
- W1597434077 hasConcept C2779780233 @default.
- W1597434077 hasConcept C2780394083 @default.
- W1597434077 hasConcept C2780664492 @default.
- W1597434077 hasConcept C2780809830 @default.
- W1597434077 hasConcept C502942594 @default.
- W1597434077 hasConcept C530470458 @default.
- W1597434077 hasConcept C543025807 @default.
- W1597434077 hasConcept C55493867 @default.
- W1597434077 hasConcept C71924100 @default.
- W1597434077 hasConcept C86803240 @default.
- W1597434077 hasConceptScore W1597434077C121608353 @default.
- W1597434077 hasConceptScore W1597434077C126322002 @default.
- W1597434077 hasConceptScore W1597434077C134018914 @default.