Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597473604> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1597473604 abstract "Initial studies on the use of non-physiological amino acids (NPAAs) to block the accretion of Phe in the brain Pahenu2-/- mice revealed that 2-aminoisobutyrate (AIB) and N-methyl-2-aminoisobutyrate (MAIB) were promising lead compounds whose pharmacokinetic parameters warranted investigation.Control and Pahenu2-/- mice received intraperitoneal NPAA treatments as test compounds (150, 300 and 500 mg/kg, 1 or 7 days;) followed by collection of sera, liver and brain. LC-MS analysis was developed to quantify both AIB and MAIB in all matrices, and pharmacokinetic parameters for distribution, partitioning, accumulation and MAIB demethylation were determined.MAIB was partially converted to AIB in vivo. AIB and MAIB partitioned similarly from sera to brain and liver, with an approximate 10-fold higher accumulation in liver compared to brain. In comparison to MAIB, AIB accumulated to approximately 3 to 7-fold higher concentration in brain. Analysis of brain and liver revealed a trend toward decreased Phe with increased MAIB sera concentration.Our data support further pharmacokinetic characterization of MAIB and AIB in preparation for further preclinical safety, toxicity and tolerability studies of both AIB and MAIB." @default.
- W1597473604 created "2016-06-24" @default.
- W1597473604 creator A5010775138 @default.
- W1597473604 creator A5012748123 @default.
- W1597473604 creator A5044817062 @default.
- W1597473604 creator A5048484701 @default.
- W1597473604 creator A5050910389 @default.
- W1597473604 creator A5080080386 @default.
- W1597473604 creator A5090516534 @default.
- W1597473604 date "2015-06-01" @default.
- W1597473604 modified "2023-10-18" @default.
- W1597473604 title "Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2−/− mice" @default.
- W1597473604 cites W1991054305 @default.
- W1597473604 cites W2014843222 @default.
- W1597473604 cites W2023253424 @default.
- W1597473604 cites W2026158953 @default.
- W1597473604 cites W2080141901 @default.
- W1597473604 cites W2080834615 @default.
- W1597473604 cites W2084435364 @default.
- W1597473604 cites W2101257555 @default.
- W1597473604 cites W2132477897 @default.
- W1597473604 cites W2138122824 @default.
- W1597473604 cites W2169476998 @default.
- W1597473604 doi "https://doi.org/10.1016/j.ymgmr.2015.03.009" @default.
- W1597473604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4478616" @default.
- W1597473604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26120559" @default.
- W1597473604 hasPublicationYear "2015" @default.
- W1597473604 type Work @default.
- W1597473604 sameAs 1597473604 @default.
- W1597473604 citedByCount "2" @default.
- W1597473604 countsByYear W15974736042016 @default.
- W1597473604 crossrefType "journal-article" @default.
- W1597473604 hasAuthorship W1597473604A5010775138 @default.
- W1597473604 hasAuthorship W1597473604A5012748123 @default.
- W1597473604 hasAuthorship W1597473604A5044817062 @default.
- W1597473604 hasAuthorship W1597473604A5048484701 @default.
- W1597473604 hasAuthorship W1597473604A5050910389 @default.
- W1597473604 hasAuthorship W1597473604A5080080386 @default.
- W1597473604 hasAuthorship W1597473604A5090516534 @default.
- W1597473604 hasBestOaLocation W15974736041 @default.
- W1597473604 hasConcept C104317684 @default.
- W1597473604 hasConcept C112705442 @default.
- W1597473604 hasConcept C126322002 @default.
- W1597473604 hasConcept C150194340 @default.
- W1597473604 hasConcept C150903083 @default.
- W1597473604 hasConcept C185592680 @default.
- W1597473604 hasConcept C190727270 @default.
- W1597473604 hasConcept C202199734 @default.
- W1597473604 hasConcept C207001950 @default.
- W1597473604 hasConcept C2777431362 @default.
- W1597473604 hasConcept C2908678361 @default.
- W1597473604 hasConcept C29730261 @default.
- W1597473604 hasConcept C515207424 @default.
- W1597473604 hasConcept C55493867 @default.
- W1597473604 hasConcept C71924100 @default.
- W1597473604 hasConcept C86803240 @default.
- W1597473604 hasConcept C98274493 @default.
- W1597473604 hasConceptScore W1597473604C104317684 @default.
- W1597473604 hasConceptScore W1597473604C112705442 @default.
- W1597473604 hasConceptScore W1597473604C126322002 @default.
- W1597473604 hasConceptScore W1597473604C150194340 @default.
- W1597473604 hasConceptScore W1597473604C150903083 @default.
- W1597473604 hasConceptScore W1597473604C185592680 @default.
- W1597473604 hasConceptScore W1597473604C190727270 @default.
- W1597473604 hasConceptScore W1597473604C202199734 @default.
- W1597473604 hasConceptScore W1597473604C207001950 @default.
- W1597473604 hasConceptScore W1597473604C2777431362 @default.
- W1597473604 hasConceptScore W1597473604C2908678361 @default.
- W1597473604 hasConceptScore W1597473604C29730261 @default.
- W1597473604 hasConceptScore W1597473604C515207424 @default.
- W1597473604 hasConceptScore W1597473604C55493867 @default.
- W1597473604 hasConceptScore W1597473604C71924100 @default.
- W1597473604 hasConceptScore W1597473604C86803240 @default.
- W1597473604 hasConceptScore W1597473604C98274493 @default.
- W1597473604 hasFunder F4320308528 @default.
- W1597473604 hasFunder F4320311248 @default.
- W1597473604 hasFunder F4320337472 @default.
- W1597473604 hasLocation W15974736041 @default.
- W1597473604 hasLocation W15974736042 @default.
- W1597473604 hasLocation W15974736043 @default.
- W1597473604 hasLocation W15974736044 @default.
- W1597473604 hasLocation W15974736045 @default.
- W1597473604 hasOpenAccess W1597473604 @default.
- W1597473604 hasPrimaryLocation W15974736041 @default.
- W1597473604 hasRelatedWork W1491964893 @default.
- W1597473604 hasRelatedWork W1906640546 @default.
- W1597473604 hasRelatedWork W1998587742 @default.
- W1597473604 hasRelatedWork W2004556784 @default.
- W1597473604 hasRelatedWork W2094219250 @default.
- W1597473604 hasRelatedWork W2379311614 @default.
- W1597473604 hasRelatedWork W2388069209 @default.
- W1597473604 hasRelatedWork W2582907174 @default.
- W1597473604 hasRelatedWork W2625601291 @default.
- W1597473604 hasRelatedWork W2753834235 @default.
- W1597473604 isParatext "false" @default.
- W1597473604 isRetracted "false" @default.
- W1597473604 magId "1597473604" @default.
- W1597473604 workType "article" @default.