Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597496282> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1597496282 endingPage "3803" @default.
- W1597496282 startingPage "3799" @default.
- W1597496282 abstract "The subcutaneous administration of colchicine encapsulated in small unilamellar vesicles reduced the initial toxicity peak and maintained for several days an adequate level of the drug in the liver. Colchicine is an excellent marker for effective liposome-hepatocyte interaction since it fulfills the following criteria: (a) When taken up by the hepatocytes within liposomes, it is active and induces the synthesis of alkaline-phosphatase two to three times over control values. The injection of at least ten times more free colchicine is necessary to attain a similar induction. (b) If released from extracellular liposomes, colchicine is cleared rapidly from the circulation. The results show that liposomes, in spite of their reduced aqueous compartment (∼ 1.0 μl/μmole of lipid), can achieve clinical utility when administered subcutaneously because of their efficient interaction with parenchymal cells and their continual arrival from the injection site." @default.
- W1597496282 created "2016-06-24" @default.
- W1597496282 creator A5026011350 @default.
- W1597496282 creator A5026268103 @default.
- W1597496282 creator A5059579114 @default.
- W1597496282 date "1986-11-01" @default.
- W1597496282 modified "2023-10-17" @default.
- W1597496282 title "Increased stimulation of alkaline phosphatase by small doses of colchicine entrapped in liposomes" @default.
- W1597496282 cites W1534854046 @default.
- W1597496282 cites W1539939143 @default.
- W1597496282 cites W1580198842 @default.
- W1597496282 cites W1611636705 @default.
- W1597496282 cites W1863392971 @default.
- W1597496282 cites W1969374259 @default.
- W1597496282 cites W1977188978 @default.
- W1597496282 cites W1990358451 @default.
- W1597496282 cites W2017885511 @default.
- W1597496282 cites W2036082242 @default.
- W1597496282 cites W2043695060 @default.
- W1597496282 cites W2043811914 @default.
- W1597496282 cites W2058615744 @default.
- W1597496282 cites W2093627967 @default.
- W1597496282 cites W2094283571 @default.
- W1597496282 cites W2096498509 @default.
- W1597496282 cites W2333783772 @default.
- W1597496282 cites W4293247451 @default.
- W1597496282 doi "https://doi.org/10.1016/0006-2952(86)90667-2" @default.
- W1597496282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3778506" @default.
- W1597496282 hasPublicationYear "1986" @default.
- W1597496282 type Work @default.
- W1597496282 sameAs 1597496282 @default.
- W1597496282 citedByCount "4" @default.
- W1597496282 countsByYear W15974962822023 @default.
- W1597496282 crossrefType "journal-article" @default.
- W1597496282 hasAuthorship W1597496282A5026011350 @default.
- W1597496282 hasAuthorship W1597496282A5026268103 @default.
- W1597496282 hasAuthorship W1597496282A5059579114 @default.
- W1597496282 hasConcept C126322002 @default.
- W1597496282 hasConcept C126894567 @default.
- W1597496282 hasConcept C130316041 @default.
- W1597496282 hasConcept C134018914 @default.
- W1597496282 hasConcept C138944611 @default.
- W1597496282 hasConcept C160160445 @default.
- W1597496282 hasConcept C178790620 @default.
- W1597496282 hasConcept C181199279 @default.
- W1597496282 hasConcept C185154212 @default.
- W1597496282 hasConcept C185592680 @default.
- W1597496282 hasConcept C202751555 @default.
- W1597496282 hasConcept C24998067 @default.
- W1597496282 hasConcept C2776200302 @default.
- W1597496282 hasConcept C2776636253 @default.
- W1597496282 hasConcept C29730261 @default.
- W1597496282 hasConcept C41625074 @default.
- W1597496282 hasConcept C55493867 @default.
- W1597496282 hasConcept C71924100 @default.
- W1597496282 hasConcept C86803240 @default.
- W1597496282 hasConcept C98274493 @default.
- W1597496282 hasConceptScore W1597496282C126322002 @default.
- W1597496282 hasConceptScore W1597496282C126894567 @default.
- W1597496282 hasConceptScore W1597496282C130316041 @default.
- W1597496282 hasConceptScore W1597496282C134018914 @default.
- W1597496282 hasConceptScore W1597496282C138944611 @default.
- W1597496282 hasConceptScore W1597496282C160160445 @default.
- W1597496282 hasConceptScore W1597496282C178790620 @default.
- W1597496282 hasConceptScore W1597496282C181199279 @default.
- W1597496282 hasConceptScore W1597496282C185154212 @default.
- W1597496282 hasConceptScore W1597496282C185592680 @default.
- W1597496282 hasConceptScore W1597496282C202751555 @default.
- W1597496282 hasConceptScore W1597496282C24998067 @default.
- W1597496282 hasConceptScore W1597496282C2776200302 @default.
- W1597496282 hasConceptScore W1597496282C2776636253 @default.
- W1597496282 hasConceptScore W1597496282C29730261 @default.
- W1597496282 hasConceptScore W1597496282C41625074 @default.
- W1597496282 hasConceptScore W1597496282C55493867 @default.
- W1597496282 hasConceptScore W1597496282C71924100 @default.
- W1597496282 hasConceptScore W1597496282C86803240 @default.
- W1597496282 hasConceptScore W1597496282C98274493 @default.
- W1597496282 hasIssue "21" @default.
- W1597496282 hasLocation W15974962821 @default.
- W1597496282 hasLocation W15974962822 @default.
- W1597496282 hasOpenAccess W1597496282 @default.
- W1597496282 hasPrimaryLocation W15974962821 @default.
- W1597496282 hasRelatedWork W1922907807 @default.
- W1597496282 hasRelatedWork W2036082242 @default.
- W1597496282 hasRelatedWork W2083932001 @default.
- W1597496282 hasRelatedWork W2124704280 @default.
- W1597496282 hasRelatedWork W2182411840 @default.
- W1597496282 hasRelatedWork W2409494250 @default.
- W1597496282 hasRelatedWork W2419425772 @default.
- W1597496282 hasRelatedWork W2595951781 @default.
- W1597496282 hasRelatedWork W4290174252 @default.
- W1597496282 hasRelatedWork W94007947 @default.
- W1597496282 hasVolume "35" @default.
- W1597496282 isParatext "false" @default.
- W1597496282 isRetracted "false" @default.
- W1597496282 magId "1597496282" @default.
- W1597496282 workType "article" @default.