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• W1597501863 startingPage "304" @default.
• W1597501863 abstract "The apolipoprotein (apo) B gene Xba I polymorphism is associated with alterations in serum lipids. Disturbances in serum lipids may be a risk factor for cholesterol gallstone disease. However, the relation between the Xba I polymorphism and cholesterol gallstones is unknown. This study was aimed at characterizing the polymorphism of the apo B gene Xba I in patients with gallbladder stones and the association of Xba I polymorphism with serum lipids. Xba I genotypes were measured by PCR-RFLP, and serum lipids assayed in 190 patients with gallbladder stones and 441 control subjects. The frequency of the X+/- genotype (20.63 vs. 7.94%) and X+ allele (10.79 vs. 3.97%) was significantly higher in the patient group than in the control group. Patients with the X+/- genotype had a significantly higher concentration of total cholesterol, low-density lipoprotein (LDL)-cholesterol, and apo B in serum than patients with the X-/- genotype. The X+ allele of the apo B gene is characterized by a higher cholesterol concentration and a higher LDL-cholesterol concentration in serum, and it may be a marker for increased risk of cholesterol gallstone disease." @default.
• W1597501863 created "2016-06-24" @default.
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• W1597501863 date "2000-04-01" @default.
• W1597501863 modified "2023-10-05" @default.
• W1597501863 title "Apolipoprotein B-100 gene<i>Xba I</i>polymorphism and cholesterol gallstone disease" @default.
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• W1597501863 doi "https://doi.org/10.1034/j.1399-0004.2000.570410.x" @default.
• W1597501863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10845572" @default.
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