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• W1597502417 abstract "New Findings What is the central question of this study? Alveolar–capillary membrane conductance for nitric oxide (measured as lung diffusion of NO; DL NO ) is not thought to be improved with regular exercise training in adult humans. The purpose was to examine the effect of regular exercise training on DL NO in unfit adult women. What is the main finding and its importance? Women performing moderate‐intensity physical activity (4–6 metabolic equivalent tasks, or METS, 800 kcal week −1 , for 6 weeks) can improve DL NO to a similar extent compared to women performing vigorous‐intensity physical activity (>6 METS, 700 kcal week −1 , for 6 weeks); however, the magnitude of improvement in DL NO will probably be small and physiologically questionable. This demonstrates that interval training may not provide additional improvements in DL NO compared with moderate‐intensity physical activity. The purpose of the study was to determine whether short‐term high‐intensity aerobic interval training improves resting pulmonary diffusing capacity for nitric oxide (DL NO ) and carbon monoxide (DL CO ). Twenty‐eight sedentary women [mean (SD) age 32 (11) years, body mass index 24.3 (5.7) kg m −2 ] were randomly assigned to either a self‐directed moderate‐intensity physical activity ( n = 14) group or a supervised high‐intensity aerobic interval training group ( n = 14). The moderate physical activity group and the aerobic interval training group increased weekly physical activity energy expenditure by 800 and 1600 kcal week −1 , respectively. After 6 weeks, aerobic capacity increased to a similar exent in both groups (mean improvement 8%, effect size 0.39). The DL NO , but not DL CO , increased to a similar extent in both groups, by 4% or 3.0 (5.7) [95% confidence interval 0.8, 5.2] ml min −1 mmHg −1 m −2 from pre‐ to post‐training (effect size 0.27). There was no correlation between the change in aerobic capacity and the change in DL NO ( P > 0.05) or between the change in aerobic capacity and the change in total weekly physical activity energy expenditure ( P > 0.05). Interval training does not provide additional improvements in DL NO or aerobic capacity compared with self‐directed moderate‐intensity physical activity (4–6 metabolic equivalent tasks, 800 kcal week −1 , for 6 weeks) in unfit women. Despite the slight improvement in both DL NO and aerobic capacity, true meaningful physiological changes in these parameters remain questionable." @default.
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• W1597502417 date "2014-02-12" @default.
• W1597502417 modified "2023-10-13" @default.
• W1597502417 title "The effect of increased physical activity on pulmonary diffusing capacity in unfit women" @default.
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• W1597502417 doi "https://doi.org/10.1113/expphysiol.2013.076406" @default.
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