Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597701963> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1597701963 endingPage "1796" @default.
- W1597701963 startingPage "1789" @default.
- W1597701963 abstract "Recently, we demonstrated that an early event in the CTL-target cell (TC) interaction is loss of TC adherence to substrate. This loss of adhesion is Ag-specific, but distinct from the lytic event because it can ensue in nominally Ca2+-free medium. In this study, we examine further the mechanism of CTL-induced loss of adhesion, concentrating mainly on the signal transduction pathway. Based on the differential sensitivity of CTL to extracellular Ca2+, protein kinase C activation/depletion and inhibition by anti-Lyt-2 (CD8) or anti-CTL receptor (TCR) reagents, we demonstrate that CTL-induced loss of adhesion can be initiated through multiple activation pathways. Although CTL-mediated lysis is restricted to a Ca2+ and protein kinase C-dependent signaling mechanism, CTL-induced loss of adhesion is initiated in the presence or absence of extracellular Ca2+ or functional protein kinase C activity. Furthermore, although under physiologic conditions, anti-CD8 or anti-TCR reagents strongly block both CTL activities, under non-lytic conditions, they fail to inhibit the ability of CTL to promote loss of adhesion. These findings implicate the participation of additional CTL-TC ligand interactions resulting in loss of adhesion, and thus, provide further evidence to support the hypothesis that CTL-induced loss of adhesion can be initiated through multiple triggering pathways." @default.
- W1597701963 created "2016-06-24" @default.
- W1597701963 creator A5002046255 @default.
- W1597701963 creator A5058401562 @default.
- W1597701963 creator A5090261588 @default.
- W1597701963 creator A5090289117 @default.
- W1597701963 date "1989-03-15" @default.
- W1597701963 modified "2023-10-17" @default.
- W1597701963 title "Cytotoxic T lymphocyte-induced loss of target cell adhesion and lysis involve common and separate signaling pathways." @default.
- W1597701963 doi "https://doi.org/10.4049/jimmunol.142.6.1789" @default.
- W1597701963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2784138" @default.
- W1597701963 hasPublicationYear "1989" @default.
- W1597701963 type Work @default.
- W1597701963 sameAs 1597701963 @default.
- W1597701963 citedByCount "7" @default.
- W1597701963 countsByYear W15977019632012 @default.
- W1597701963 crossrefType "journal-article" @default.
- W1597701963 hasAuthorship W1597701963A5002046255 @default.
- W1597701963 hasAuthorship W1597701963A5058401562 @default.
- W1597701963 hasAuthorship W1597701963A5090261588 @default.
- W1597701963 hasAuthorship W1597701963A5090289117 @default.
- W1597701963 hasBestOaLocation W15977019631 @default.
- W1597701963 hasConcept C147969180 @default.
- W1597701963 hasConcept C1491633281 @default.
- W1597701963 hasConcept C154317977 @default.
- W1597701963 hasConcept C167672396 @default.
- W1597701963 hasConcept C182615771 @default.
- W1597701963 hasConcept C185592680 @default.
- W1597701963 hasConcept C19317047 @default.
- W1597701963 hasConcept C202751555 @default.
- W1597701963 hasConcept C203014093 @default.
- W1597701963 hasConcept C2522874641 @default.
- W1597701963 hasConcept C2776090121 @default.
- W1597701963 hasConcept C28406088 @default.
- W1597701963 hasConcept C55493867 @default.
- W1597701963 hasConcept C62478195 @default.
- W1597701963 hasConcept C85789140 @default.
- W1597701963 hasConcept C86803240 @default.
- W1597701963 hasConcept C8891405 @default.
- W1597701963 hasConcept C95444343 @default.
- W1597701963 hasConceptScore W1597701963C147969180 @default.
- W1597701963 hasConceptScore W1597701963C1491633281 @default.
- W1597701963 hasConceptScore W1597701963C154317977 @default.
- W1597701963 hasConceptScore W1597701963C167672396 @default.
- W1597701963 hasConceptScore W1597701963C182615771 @default.
- W1597701963 hasConceptScore W1597701963C185592680 @default.
- W1597701963 hasConceptScore W1597701963C19317047 @default.
- W1597701963 hasConceptScore W1597701963C202751555 @default.
- W1597701963 hasConceptScore W1597701963C203014093 @default.
- W1597701963 hasConceptScore W1597701963C2522874641 @default.
- W1597701963 hasConceptScore W1597701963C2776090121 @default.
- W1597701963 hasConceptScore W1597701963C28406088 @default.
- W1597701963 hasConceptScore W1597701963C55493867 @default.
- W1597701963 hasConceptScore W1597701963C62478195 @default.
- W1597701963 hasConceptScore W1597701963C85789140 @default.
- W1597701963 hasConceptScore W1597701963C86803240 @default.
- W1597701963 hasConceptScore W1597701963C8891405 @default.
- W1597701963 hasConceptScore W1597701963C95444343 @default.
- W1597701963 hasIssue "6" @default.
- W1597701963 hasLocation W15977019631 @default.
- W1597701963 hasLocation W15977019632 @default.
- W1597701963 hasOpenAccess W1597701963 @default.
- W1597701963 hasPrimaryLocation W15977019631 @default.
- W1597701963 hasRelatedWork W1967448469 @default.
- W1597701963 hasRelatedWork W2018916009 @default.
- W1597701963 hasRelatedWork W2038421035 @default.
- W1597701963 hasRelatedWork W2050790509 @default.
- W1597701963 hasRelatedWork W2054101033 @default.
- W1597701963 hasRelatedWork W2087538468 @default.
- W1597701963 hasRelatedWork W2089544888 @default.
- W1597701963 hasRelatedWork W2101380139 @default.
- W1597701963 hasRelatedWork W2125066454 @default.
- W1597701963 hasRelatedWork W2153028546 @default.
- W1597701963 hasVolume "142" @default.
- W1597701963 isParatext "false" @default.
- W1597701963 isRetracted "false" @default.
- W1597701963 magId "1597701963" @default.
- W1597701963 workType "article" @default.