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- W1597707908 abstract "In Chapter 2, we saw that the exposure of organisms to toxic agents in the environment may result in adverse effects if the exposure concentration and time exceed certain thresholds. A primary goal of toxicologists is to establish a quantitative relationship between toxic exposure and degree of effect. Usually this takes the form of a dose-response curve, although in environmental toxicology we often use the concentration of the toxicant in the exposure medium as a substitute for dose. In doing so, we are assuming that the ambient toxicant concentration has a direct relationship to the dose accumulated by the organism, even though we may choose not to quantify the dose during a bioassay. Although such an assumption seems reasonable, a variety of extraneous factors, individually and collectively, may significantly affect this relationship by varying the bioavailability of a toxic chemical or by altering its metabolism." @default.
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- W1597707908 date "2002-03-14" @default.
- W1597707908 modified "2023-09-25" @default.
- W1597707908 title "Factors affecting toxicity" @default.
- W1597707908 doi "https://doi.org/10.1017/cbo9780511805998.007" @default.
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