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- W1597885820 endingPage "340" @default.
- W1597885820 startingPage "330" @default.
- W1597885820 abstract "Purinergic signalling is implicated in virtually any cellular and physiological function. These functions are mediated through the activation of different receptor subfamilies, among which P2X receptors (P2XRs) are ligand-gated ion channels that respond mostly to ATP. In addition to forming a nonselective cation channel, these receptors engage with a complex network of signalling pathways, including protein kinase cascades, lipid signal mediators and proteases. It is poorly understood how P2XR stimulation couples to such a variety of intracellular pathways and how the outcome from this complex signalling network is tuned. In this context, segregation of receptors and other signalling components at the plasma membrane is an attractive explanation. Lipid rafts are microdomains of biological membranes with unique physicochemical properties that make them segregate from the bulk of the membrane, provoking the differential partition of receptors and signalling molecules among different domains of the plasma membrane. Here we give an overview of the properties of lipid rafts and how they are studied, along with recent advances in the understanding of their role in modulating P2XR-mediated signalling." @default.
- W1597885820 created "2016-06-24" @default.
- W1597885820 creator A5010212856 @default.
- W1597885820 creator A5041608898 @default.
- W1597885820 creator A5070810300 @default.
- W1597885820 date "2008-12-09" @default.
- W1597885820 modified "2023-10-18" @default.
- W1597885820 title "Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling" @default.
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