Matches in SemOpenAlex for { <https://semopenalex.org/work/W1597899314> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W1597899314 endingPage "626" @default.
- W1597899314 startingPage "620" @default.
- W1597899314 abstract "CD40 is an integral membrane glycoprotein found on the surface of human B lymphocytes. Antibodies specific for CD40 have been shown to augment proliferation of activated B lymphocytes, prevent B lymphocyte apoptosis, and prolong the maintenance of normal B lymphocytes in culture. As a step toward developing an in vivo system to examine CD40 function, a molecular clone encoding the murine homologue of the human CD40 B lymphocyte surface Ag was isolated and characterized. Throughout their open reading frames, the murine and human proteins shared 62% predicted amino acid identity. Within the cytoplasmic domain, which includes a completely conserved region known to be important for signaling by human CD40, the CD40 homologues are 78% identical. The human and murine proteins are members of a new cytokine receptor family, which includes the receptors for nerve growth factor and TNF-alpha, that are homologous in their cysteine-rich extracellular domains. The murine CD40 gene is expressed in B lymphocytes as two mRNA species generated by alternative usage of polyadenylation signals in the 3' untranslated region. The activation of B lymphocytes differentially increases the relative levels of these two mRNA transcripts suggesting a posttranscriptional mechanism for the regulation of CD40 surface expression." @default.
- W1597899314 created "2016-06-24" @default.
- W1597899314 creator A5004809714 @default.
- W1597899314 creator A5020535485 @default.
- W1597899314 date "1992-01-15" @default.
- W1597899314 modified "2023-10-12" @default.
- W1597899314 title "Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation." @default.
- W1597899314 doi "https://doi.org/10.4049/jimmunol.148.2.620" @default.
- W1597899314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1370315" @default.
- W1597899314 hasPublicationYear "1992" @default.
- W1597899314 type Work @default.
- W1597899314 sameAs 1597899314 @default.
- W1597899314 citedByCount "47" @default.
- W1597899314 countsByYear W15978993142012 @default.
- W1597899314 countsByYear W15978993142013 @default.
- W1597899314 countsByYear W15978993142014 @default.
- W1597899314 crossrefType "journal-article" @default.
- W1597899314 hasAuthorship W1597899314A5004809714 @default.
- W1597899314 hasAuthorship W1597899314A5020535485 @default.
- W1597899314 hasBestOaLocation W15978993141 @default.
- W1597899314 hasConcept C104317684 @default.
- W1597899314 hasConcept C105580179 @default.
- W1597899314 hasConcept C142575336 @default.
- W1597899314 hasConcept C153911025 @default.
- W1597899314 hasConcept C154317977 @default.
- W1597899314 hasConcept C170493617 @default.
- W1597899314 hasConcept C202751555 @default.
- W1597899314 hasConcept C39347974 @default.
- W1597899314 hasConcept C55493867 @default.
- W1597899314 hasConcept C86803240 @default.
- W1597899314 hasConcept C95444343 @default.
- W1597899314 hasConceptScore W1597899314C104317684 @default.
- W1597899314 hasConceptScore W1597899314C105580179 @default.
- W1597899314 hasConceptScore W1597899314C142575336 @default.
- W1597899314 hasConceptScore W1597899314C153911025 @default.
- W1597899314 hasConceptScore W1597899314C154317977 @default.
- W1597899314 hasConceptScore W1597899314C170493617 @default.
- W1597899314 hasConceptScore W1597899314C202751555 @default.
- W1597899314 hasConceptScore W1597899314C39347974 @default.
- W1597899314 hasConceptScore W1597899314C55493867 @default.
- W1597899314 hasConceptScore W1597899314C86803240 @default.
- W1597899314 hasConceptScore W1597899314C95444343 @default.
- W1597899314 hasIssue "2" @default.
- W1597899314 hasLocation W15978993141 @default.
- W1597899314 hasLocation W15978993142 @default.
- W1597899314 hasOpenAccess W1597899314 @default.
- W1597899314 hasPrimaryLocation W15978993141 @default.
- W1597899314 hasRelatedWork W1850799531 @default.
- W1597899314 hasRelatedWork W1981662335 @default.
- W1597899314 hasRelatedWork W1983255013 @default.
- W1597899314 hasRelatedWork W2009966535 @default.
- W1597899314 hasRelatedWork W2074050642 @default.
- W1597899314 hasRelatedWork W2088063203 @default.
- W1597899314 hasRelatedWork W2092538393 @default.
- W1597899314 hasRelatedWork W2171277769 @default.
- W1597899314 hasRelatedWork W2344678176 @default.
- W1597899314 hasRelatedWork W2417081525 @default.
- W1597899314 hasVolume "148" @default.
- W1597899314 isParatext "false" @default.
- W1597899314 isRetracted "false" @default.
- W1597899314 magId "1597899314" @default.
- W1597899314 workType "article" @default.