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- W1597929599 abstract "Cost-effective production of commercial-scale batches of pharmaceutical-grade plasmid DNA remains a challenge for the maturing industry of plasmid-based biologics. A process is required that meets the quality standards for human pharmaceutical products and yet is economically suitable for use in veterinary medicine or as an in-process product for viral therapeutic production. Previously described scaleable cell lysis requires a substantial capital investment. Also, these techniques contaminate the process stream with unnecessary impurity levels. A simple, effective purification strategy requires elimination of all animal-derived enzymes, without adding costly column-based chromatography steps. The method described herein has produced multi-gram batches of pharmaceutical-grade plasmid at a fraction of the cost of previously described methods." @default.
- W1597929599 created "2016-06-24" @default.
- W1597929599 date "2004-05-01" @default.
- W1597929599 modified "2023-09-24" @default.
- W1597929599 title "Cost-effective, pharmaceutical-grade plasmid production method for commercial use" @default.
- W1597929599 doi "https://doi.org/10.1016/j.ymthe.2004.06.718" @default.
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