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- W1597932990 abstract "Infection and inflammation are critical in the progression of cystic fibrosis (CF) lung disease, and are the cause of death of most patients. Therefore, understanding their origins and mechanisms is critical to designing effective interventions. Bacterial infection in CF occurs in the wake of ion transport abnormalities that thwart the usual mucociliary clearance mechanisms, but may also be promoted by excess adhesion of particular bacteria to the CF airway and by protracted inflammatory responses to prior viral infections, leaving the airway vulnerable. Once initiated by infection (or perhaps, even before infection sets in), the inflammatory process in CF airways is excessive relative to the stimulus applied, protracted, and fails to resolve appropriately, even if the infectious stimulus is removed.Whether this is driven by epithelial responses, the responses of other immune cells, or, most likely, some interaction of the vulnerable cell types in the lung, is not yet clear. Moreover, the precise intracellular abnormalities that produce this phenotype are still being elucidated, and their relationship to CFTR dysfunction is similarly unclear. Nevertheless, infection and inflammation remain the two most attractive independent therapeutic targets in CF, short of the basic defect itself. In this chapter, we examine the relationship between infection and inflammation in CF lung disease." @default.
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- W1597932990 date "2005-01-01" @default.
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- W1597932990 title "Infection versus Inflammation" @default.
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- W1597932990 doi "https://doi.org/10.1159/000088490" @default.
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