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• W159794491 abstract "Experiments were conducted, using microspectrophotometry and radioautography, to determine the effect of four different viruses on the nucleic acid metabolism of the mouse cell line F120E90. The viruses utilized for this study were Herpes simplex virus, Western equine encephalomyelitis virus. Type I poliovirus, and Friend leukemia virus. For microspectrophotometry, nucleic acid metabol­ ism was studied by methylene blue, which stains both DNA and RNA, and the Feulgen stain, which is specific for DNA. The stained cells, virusinoculated and non-inoculated, were measured by the twowavelength method on a Leitz microspectrophotometer. The methylene blue preparations were read at 600 mn and 570 m^i; the Feulgen pre­ parations were read at 550 m/i and 500 m/u. The relative amount of bound chromophore for each cell was computed by a CDC 6400 com­ puter. For radioautography, tritiated thymidine and tritiated uridine were utilized for DNA and RNA, respectively. Grain counts were performed to delineate differences between virus-inoculated and non-inoculated cells. Each of the viruses with the exception of poliovirus affected a measurable change in either DNA, RNA, or both. These changes represented the nucleic acid metabolic pattern of virus-cell interaction. vi vii Herpes simplex virus increased both DNA and RNA during a 10 hour interval following inoculation. Western equine encephalomyelitis virus increased RNA from 6 to 12 hours post inoculation. Type I poliovirus did not affect nucleic acid metabolism. Friend leukemia virus increased both DNA and RNA during a 10 hour interval following inoculation. During a six day study. Friend leukemia virus also in­ creased RNA; however, this increase reached a maximum at three days PI. It is suggested that in situations where virus-cell interaction is not grossly apparent, microspectrophotometry utilizing methylene blue and Feulgen might be used to detect and quantitate the respective interaction." @default.
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• W159794491 date "1969-01-01" @default.
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• W159794491 title "MICROSPECTROPHOTOMETRIC DETERMINATION OF NUCLEIC ACIDS IN NORMAL AND IN VIRUS-INFECTED TISSUE CULTURE CELLS" @default.
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