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• W1598020930 abstract "Recent developments in the field of antineoplastic principles in plants can be summarized in terms of specific compounds that have been isolated, certain generalizations that can be made, and fringe benefits in phytochemistry. This chapter discusses such recent progress in this field. For this purpose, the chapter restricts its discussion by defining the limits by “plants” meant those that are commonly called higher plants and ferns or, more properly, spermatophytes (phanerogams) and pteridophytes. The chapter excludes lower forms of plants, except in a few cases where appropriate substances obtained from these forms serve to contribute to the discussion. Antineoplastic activity discussed implies activity in experimental tumors only. The chapter has adopted such restriction, as it has a certain advantage— namely, that all the screening results reported have been obtained under generally uniform experimental procedures. From the chapter, it is apparent that one of the main hopes originally held for this work is being realized— namely, that higher plants are yielding chemical compounds of a wide variety of types: alkaloids, sesquiterpene lactones, saponins, digitaloid glycosides, quinones, and proteins among others, active against many different experimental tumor systems. Furthermore, most of these compounds would have been inaccessible until their isolation from natural sources, because not only would there be no particular reason for attempted synthesis but also many of them could be synthesized only with severe difficulty. As these compounds are subjected to extensive pharmacological testing designed to select out those that have clinical promise, most of them are eliminated as is to be expected. However, a sufficient proportion of them passes the criteria and reaches the level of clinical trial as to justify the large effort involved in the whole process." @default.
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• W1598020930 title "Antineoplastic Principles in Plants: Recent Developments in the Field" @default.
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• W1598020930 doi "https://doi.org/10.1016/s1054-3589(08)60561-x" @default.
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