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- W1598033019 abstract "Allogeneic stem cell transplantation is a curative treatment for adult acute leukemias aiming to eradicate the malignant clone using a conditioning regimen and the immunological conflict inherent to donor hematopoietic stem cells installation in the recipient. The use of sibling allografting is increasing in parallel with an increase in matched unrelated donor transplantations. The different possible sources of hematopoietic stem cells and a better knowledge of HLA typing have led to the improvement in patient survival and to the extension of allograft indications. For acute myeloid leukemia (AML) patients receiving an HLA‐identical sibling allograft in first remission, there is a 50 to 60% likelihood of leukemia‐free survival. Allogeneic bone marrow transplantation is also an integral part of the treatment strategy for adult acute lymphoblastic leukemia (ALL). The leukemia‐free survival rates for adult ALL patients transplanted in first remission are 50% at 3 to 7 years. Most complications following allogeneic transplantation are related to reactions of the graft against the host. The post‐transplantation period can also be riddled with various complications such as veno‐occlusive disease, endocrine complications, as well as complications arising from infections and secondary neoplasms because of a more or less substantial and durable immune deficiency. Non‐myeloablative stem cell transplantation (minitransplant’) is another approach to utilizing graft versus leukemia effects and may lead to an extension of the upper age limit for allogeneic stem cell transplantation." @default.
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- W1598033019 date "2004-05-01" @default.
- W1598033019 modified "2023-09-23" @default.
- W1598033019 title "Allogeneic stem cell transplantation in adult acute leukemias: long‐term follow‐up" @default.
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