FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1598045648> ?p ?o ?g. }

• W1598045648 endingPage "24705" @default.
• W1598045648 startingPage "24699" @default.
• W1598045648 abstract "We report here the detailed analysis of the promoter of a thyroid hormone receptor (TR) gene that is regulated by the hormone itself. The receptor gene, TR beta A, is one of the two TR beta genes in Xenopus laevis. It has two transcription start sites. The mRNAs derived from one of them are up-regulated by thyroid hormone, whereas those derived from the other are independent of the hormone. We have characterized the hormone-inducible promoter using a transient transfection assay in a Xenopus tissue culture cell line (A6). Deletion and mutational analysis identifies the first amphibian thyroid hormone response element (TRE). This TRE consists of near perfect direct repeats of AGGTCA with a 4-base pair spacing similar to mammalian TREs. The TRE forms specific complexes with extracts of A6 cells that have similar sequence specificities as those found for the complexes between mammalian TRs and TREs. However, unlike TREs found in other thyroid hormone-inducible promoters, this TRE is located at the putative transcription start site and mediates transcriptional repression by unliganded TRs. The addition of thyroid hormone at physiological concentrations overcomes the repression and induces further transcriptional activation at higher concentrations. These results suggest a potential mechanism for the regulation of amphibian metamorphosis, a process that is entirely controlled by thyroid hormone." @default.
• W1598045648 created "2016-06-24" @default.
• W1598045648 creator A5036136202 @default.
• W1598045648 creator A5038200182 @default.
• W1598045648 creator A5072720344 @default.
• W1598045648 date "1994-10-01" @default.
• W1598045648 modified "2023-10-18" @default.
• W1598045648 title "Transcriptional repression of Xenopus TR beta gene is mediated by a thyroid hormone response element located near the start site." @default.
• W1598045648 cites W135983215 @default.
• W1598045648 cites W1483306026 @default.
• W1598045648 cites W1494125107 @default.
• W1598045648 cites W1557168768 @default.
• W1598045648 cites W1575265914 @default.
• W1598045648 cites W1583104418 @default.
• W1598045648 cites W1583559371 @default.
• W1598045648 cites W1661198189 @default.
• W1598045648 cites W1663165115 @default.
• W1598045648 cites W1932076246 @default.
• W1598045648 cites W1962551859 @default.
• W1598045648 cites W1967161001 @default.
• W1598045648 cites W1981474173 @default.
• W1598045648 cites W1984509210 @default.
• W1598045648 cites W1985247182 @default.
• W1598045648 cites W1987067177 @default.
• W1598045648 cites W1990437398 @default.
• W1598045648 cites W1990675136 @default.
• W1598045648 cites W1992032967 @default.
• W1598045648 cites W1992289621 @default.
• W1598045648 cites W1998125794 @default.
• W1598045648 cites W1998902933 @default.
• W1598045648 cites W2000148292 @default.
• W1598045648 cites W2000902147 @default.
• W1598045648 cites W2011467252 @default.
• W1598045648 cites W2020624387 @default.
• W1598045648 cites W2031040058 @default.
• W1598045648 cites W2032694235 @default.
• W1598045648 cites W2041270901 @default.
• W1598045648 cites W2049862742 @default.
• W1598045648 cites W2050340166 @default.
• W1598045648 cites W2060903877 @default.
• W1598045648 cites W2068341645 @default.
• W1598045648 cites W2071263405 @default.
• W1598045648 cites W2071462924 @default.
• W1598045648 cites W2085124463 @default.
• W1598045648 cites W2089029040 @default.
• W1598045648 cites W2090024435 @default.
• W1598045648 cites W2096258929 @default.
• W1598045648 cites W2102082802 @default.
• W1598045648 cites W2112823160 @default.
• W1598045648 cites W2117825435 @default.
• W1598045648 cites W2118516988 @default.
• W1598045648 cites W2120176836 @default.
• W1598045648 cites W2130929794 @default.
• W1598045648 cites W2139741535 @default.
• W1598045648 cites W2157589212 @default.
• W1598045648 cites W2162702340 @default.
• W1598045648 doi "https://doi.org/10.1016/s0021-9258(17)31447-3" @default.
• W1598045648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7929143" @default.
• W1598045648 hasPublicationYear "1994" @default.
• W1598045648 type Work @default.
• W1598045648 sameAs 1598045648 @default.
• W1598045648 citedByCount "178" @default.
• W1598045648 countsByYear W15980456482012 @default.
• W1598045648 countsByYear W15980456482013 @default.
• W1598045648 countsByYear W15980456482014 @default.
• W1598045648 countsByYear W15980456482015 @default.
• W1598045648 countsByYear W15980456482016 @default.
• W1598045648 countsByYear W15980456482017 @default.
• W1598045648 countsByYear W15980456482018 @default.
• W1598045648 countsByYear W15980456482019 @default.
• W1598045648 countsByYear W15980456482020 @default.
• W1598045648 countsByYear W15980456482021 @default.
• W1598045648 countsByYear W15980456482022 @default.
• W1598045648 countsByYear W15980456482023 @default.
• W1598045648 crossrefType "journal-article" @default.
• W1598045648 hasAuthorship W1598045648A5036136202 @default.
• W1598045648 hasAuthorship W1598045648A5038200182 @default.
• W1598045648 hasAuthorship W1598045648A5072720344 @default.
• W1598045648 hasBestOaLocation W15980456481 @default.
• W1598045648 hasConcept C104317684 @default.
• W1598045648 hasConcept C121608353 @default.
• W1598045648 hasConcept C126322002 @default.
• W1598045648 hasConcept C134018914 @default.
• W1598045648 hasConcept C150194340 @default.
• W1598045648 hasConcept C153911025 @default.
• W1598045648 hasConcept C185592680 @default.
• W1598045648 hasConcept C186310378 @default.
• W1598045648 hasConcept C199360897 @default.
• W1598045648 hasConcept C2776174256 @default.
• W1598045648 hasConcept C2779535977 @default.
• W1598045648 hasConcept C41008148 @default.
• W1598045648 hasConcept C51445715 @default.
• W1598045648 hasConcept C526584372 @default.
• W1598045648 hasConcept C530470458 @default.
• W1598045648 hasConcept C54355233 @default.
• W1598045648 hasConcept C71315377 @default.
• W1598045648 hasConcept C71924100 @default.
• W1598045648 hasConcept C84606932 @default.

• next