FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1598052190> ?p ?o ?g. }

• W1598052190 endingPage "1043" @default.
• W1598052190 startingPage "1036" @default.
• W1598052190 abstract "Mutations of Fas (lpr) or Fas ligand (gld) cause a limited lupus-like syndrome in B6 mice by interfering with the deletion of autoreactive B and/or T cells. A more generalized lupus syndrome reminiscent of that of MRL mice can be induced in nonautoimmune strains by pristane, which causes a nonspecific inflammatory response in the peritoneal cavity. We hypothesized that, as in MRL mice, the lpr and gld mutations might accelerate lupus in pristane-treated mice. Pristane-treated B6 mice developed anti-nRNP/Sm, Su, and ribosomal P Abs, but little anti-ssDNA or chromatin. In contrast, B6/lpr and B6/gld mice spontaneously developed anti-ssDNA/chromatin Abs, but not anti-nRNP/Sm/Su/ribosomal P. Unexpectedly, B6/lpr and B6/gld mice were highly resistant to the induction by pristane of IgM anti-ssDNA (2 wk) and IgG anti-nRNP/Sm/Su/ribosomal P autoantibodies (6 mo), suggesting that intact Fas signaling is necessary. Interestingly, pristane did not enhance IgG chromatin Ab production in B6/lpr or B6/gld mice, suggesting that it did not influence the production of autoantibodies that develop spontaneously in the setting of Fas deficiency. Pristane treatment also decreased lymphoproliferation in B6/lpr mice. Increased production of IL-12 was associated consistently with the production of anti-nRNP/Sm/Su/ribosomal P as well as anti-DNA/chromatin. In contrast, production of anti-DNA/chromatin Abs was associated with IL-6 overproduction in pristane-treated mice, but not in lpr mice. The data strongly support the idea that different subsets of autoantibodies are regulated differentially by cytokine stimulation and/or Fas signaling." @default.
• W1598052190 created "2016-06-24" @default.
• W1598052190 creator A5014633771 @default.
• W1598052190 creator A5016651473 @default.
• W1598052190 creator A5022870216 @default.
• W1598052190 creator A5028340044 @default.
• W1598052190 creator A5029479045 @default.
• W1598052190 creator A5044297659 @default.
• W1598052190 creator A5081915558 @default.
• W1598052190 date "2000-07-15" @default.
• W1598052190 modified "2023-09-26" @default.
• W1598052190 title "Fas and Fas Ligand Mutations Inhibit Autoantibody Production in Pristane-Induced Lupus" @default.
• W1598052190 cites W1485265843 @default.
• W1598052190 cites W1498105805 @default.
• W1598052190 cites W1592443709 @default.
• W1598052190 cites W1850716758 @default.
• W1598052190 cites W1903605698 @default.
• W1598052190 cites W1947598746 @default.
• W1598052190 cites W1963558993 @default.
• W1598052190 cites W1972976000 @default.
• W1598052190 cites W1973198631 @default.
• W1598052190 cites W1985985556 @default.
• W1598052190 cites W1991212304 @default.
• W1598052190 cites W1991476335 @default.
• W1598052190 cites W1997388913 @default.
• W1598052190 cites W2003955248 @default.
• W1598052190 cites W2009509313 @default.
• W1598052190 cites W2009652380 @default.
• W1598052190 cites W2013281032 @default.
• W1598052190 cites W2016808992 @default.
• W1598052190 cites W2017628675 @default.
• W1598052190 cites W2037217504 @default.
• W1598052190 cites W2050594030 @default.
• W1598052190 cites W2053772964 @default.
• W1598052190 cites W2060220551 @default.
• W1598052190 cites W2065727164 @default.
• W1598052190 cites W2077594740 @default.
• W1598052190 cites W2082558653 @default.
• W1598052190 cites W2082622484 @default.
• W1598052190 cites W2096658609 @default.
• W1598052190 cites W2102812821 @default.
• W1598052190 cites W2110062258 @default.
• W1598052190 cites W2115375944 @default.
• W1598052190 cites W2116627264 @default.
• W1598052190 cites W2123412929 @default.
• W1598052190 cites W2125597028 @default.
• W1598052190 cites W2134341159 @default.
• W1598052190 cites W2140582776 @default.
• W1598052190 cites W2158500407 @default.
• W1598052190 cites W2161669288 @default.
• W1598052190 cites W2161996856 @default.
• W1598052190 cites W2179862924 @default.
• W1598052190 cites W4313341441 @default.
• W1598052190 doi "https://doi.org/10.4049/jimmunol.165.2.1036" @default.
• W1598052190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10878381" @default.
• W1598052190 hasPublicationYear "2000" @default.
• W1598052190 type Work @default.
• W1598052190 sameAs 1598052190 @default.
• W1598052190 citedByCount "64" @default.
• W1598052190 countsByYear W15980521902012 @default.
• W1598052190 countsByYear W15980521902013 @default.
• W1598052190 countsByYear W15980521902014 @default.
• W1598052190 countsByYear W15980521902015 @default.
• W1598052190 countsByYear W15980521902017 @default.
• W1598052190 countsByYear W15980521902018 @default.
• W1598052190 countsByYear W15980521902019 @default.
• W1598052190 countsByYear W15980521902020 @default.
• W1598052190 countsByYear W15980521902021 @default.
• W1598052190 countsByYear W15980521902022 @default.
• W1598052190 crossrefType "journal-article" @default.
• W1598052190 hasAuthorship W1598052190A5014633771 @default.
• W1598052190 hasAuthorship W1598052190A5016651473 @default.
• W1598052190 hasAuthorship W1598052190A5022870216 @default.
• W1598052190 hasAuthorship W1598052190A5028340044 @default.
• W1598052190 hasAuthorship W1598052190A5029479045 @default.
• W1598052190 hasAuthorship W1598052190A5044297659 @default.
• W1598052190 hasAuthorship W1598052190A5081915558 @default.
• W1598052190 hasBestOaLocation W15980521901 @default.
• W1598052190 hasConcept C126322002 @default.
• W1598052190 hasConcept C153911025 @default.
• W1598052190 hasConcept C159654299 @default.
• W1598052190 hasConcept C163764329 @default.
• W1598052190 hasConcept C178790620 @default.
• W1598052190 hasConcept C185592680 @default.
• W1598052190 hasConcept C203014093 @default.
• W1598052190 hasConcept C2775915377 @default.
• W1598052190 hasConcept C2776912625 @default.
• W1598052190 hasConcept C2777207669 @default.
• W1598052190 hasConcept C2779134260 @default.
• W1598052190 hasConcept C2780130043 @default.
• W1598052190 hasConcept C2780804346 @default.
• W1598052190 hasConcept C71924100 @default.
• W1598052190 hasConcept C86803240 @default.
• W1598052190 hasConceptScore W1598052190C126322002 @default.
• W1598052190 hasConceptScore W1598052190C153911025 @default.
• W1598052190 hasConceptScore W1598052190C159654299 @default.
• W1598052190 hasConceptScore W1598052190C163764329 @default.
• W1598052190 hasConceptScore W1598052190C178790620 @default.

• next