FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1598053850> ?p ?o ?g. }

• W1598053850 endingPage "548" @default.
• W1598053850 startingPage "543" @default.
• W1598053850 abstract "The ability of adenyl-5'-yl imidodiphosphate (AMP-PNP), ADP, and PPi to dissociate the actin.myosin subfragment 1 (S-1) complex was studied using an analytical ultracentrifuge with UV optics, which enabled the direct determination of the dissociated S-1. At mu = 0.22 M, pH 7.0, 22 degrees C, with saturating nucleotide present, ADP weakens the binding of S-1 to actin about 40-fold (K congruent to 10(5) M-1), while both AMP-PNP and PPi weakens the binding about 400-fold (K congruent to 10(4) M-1). This 10-fold stronger dissociating effect of AMP-PNP and PPi compared to ADP correlates with our data showing that the binding of AMP-PNP and PPi to S-1 is about 10-fold stronger than the binding of ADP. In contrast, the binding constants of ADP, AMP-PNP, and PPi to acto.S-1 are nearly identical (K congruent to 5 x 10(3) M-1). At 4 degrees C, AMP-PNP has only a 3-fold stronger dissociating effect than ADP and, similarly, our data suggest that the binding of AMP-PNP and ADP to S-1 is quite similar at 4 degrees C. AMP-PNP and PPi are, therefore, somewhat better dissociating agents than ADP, but the difference among these three ligands is quite small. These data also show that actin and nucleotide bind to separate but interacting sites on S-1 and that the S-1 molecules bind independently along the F-actin filament with a binding constant of about 1 x 10(7) M-1 at 22 degrees C and physiological ionic strength." @default.
• W1598053850 created "2016-06-24" @default.
• W1598053850 creator A5004657382 @default.
• W1598053850 creator A5066697360 @default.
• W1598053850 date "1980-01-01" @default.
• W1598053850 modified "2023-09-30" @default.
• W1598053850 title "Dissociation of the actin.subfragment 1 complex by adenyl-5'-yl imidodiphosphate, ADP, and PPi." @default.
• W1598053850 cites W11858349 @default.
• W1598053850 cites W1530055571 @default.
• W1598053850 cites W1538692246 @default.
• W1598053850 cites W1569313009 @default.
• W1598053850 cites W1570077039 @default.
• W1598053850 cites W1595043423 @default.
• W1598053850 cites W1913326387 @default.
• W1598053850 cites W1963826738 @default.
• W1598053850 cites W1969301033 @default.
• W1598053850 cites W1971819609 @default.
• W1598053850 cites W1972557958 @default.
• W1598053850 cites W1981983192 @default.
• W1598053850 cites W2000888880 @default.
• W1598053850 cites W2003001614 @default.
• W1598053850 cites W2004057219 @default.
• W1598053850 cites W2004543315 @default.
• W1598053850 cites W2007126594 @default.
• W1598053850 cites W2007751924 @default.
• W1598053850 cites W2008745175 @default.
• W1598053850 cites W2014410243 @default.
• W1598053850 cites W2022302833 @default.
• W1598053850 cites W2022809164 @default.
• W1598053850 cites W2026145805 @default.
• W1598053850 cites W2033317179 @default.
• W1598053850 cites W2050066926 @default.
• W1598053850 cites W2051774176 @default.
• W1598053850 cites W2053788196 @default.
• W1598053850 cites W2054438745 @default.
• W1598053850 cites W2061472229 @default.
• W1598053850 cites W2067190245 @default.
• W1598053850 cites W2069445258 @default.
• W1598053850 cites W2069625615 @default.
• W1598053850 cites W2077074448 @default.
• W1598053850 cites W2081554678 @default.
• W1598053850 cites W2088049715 @default.
• W1598053850 cites W2127053077 @default.
• W1598053850 cites W2141431390 @default.
• W1598053850 cites W2148984820 @default.
• W1598053850 cites W2167313334 @default.
• W1598053850 cites W2242855238 @default.
• W1598053850 cites W2416608665 @default.
• W1598053850 doi "https://doi.org/10.1016/s0021-9258(19)86209-9" @default.
• W1598053850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6243280" @default.
• W1598053850 hasPublicationYear "1980" @default.
• W1598053850 type Work @default.
• W1598053850 sameAs 1598053850 @default.
• W1598053850 citedByCount "149" @default.
• W1598053850 countsByYear W15980538502012 @default.
• W1598053850 countsByYear W15980538502015 @default.
• W1598053850 countsByYear W15980538502017 @default.
• W1598053850 countsByYear W15980538502018 @default.
• W1598053850 countsByYear W15980538502019 @default.
• W1598053850 crossrefType "journal-article" @default.
• W1598053850 hasAuthorship W1598053850A5004657382 @default.
• W1598053850 hasAuthorship W1598053850A5066697360 @default.
• W1598053850 hasBestOaLocation W15980538501 @default.
• W1598053850 hasConcept C102931765 @default.
• W1598053850 hasConcept C12554922 @default.
• W1598053850 hasConcept C125705527 @default.
• W1598053850 hasConcept C178790620 @default.
• W1598053850 hasConcept C185592680 @default.
• W1598053850 hasConcept C203014093 @default.
• W1598053850 hasConcept C2777399203 @default.
• W1598053850 hasConcept C2993802102 @default.
• W1598053850 hasConcept C55493867 @default.
• W1598053850 hasConcept C86803240 @default.
• W1598053850 hasConcept C89560881 @default.
• W1598053850 hasConceptScore W1598053850C102931765 @default.
• W1598053850 hasConceptScore W1598053850C12554922 @default.
• W1598053850 hasConceptScore W1598053850C125705527 @default.
• W1598053850 hasConceptScore W1598053850C178790620 @default.
• W1598053850 hasConceptScore W1598053850C185592680 @default.
• W1598053850 hasConceptScore W1598053850C203014093 @default.
• W1598053850 hasConceptScore W1598053850C2777399203 @default.
• W1598053850 hasConceptScore W1598053850C2993802102 @default.
• W1598053850 hasConceptScore W1598053850C55493867 @default.
• W1598053850 hasConceptScore W1598053850C86803240 @default.
• W1598053850 hasConceptScore W1598053850C89560881 @default.
• W1598053850 hasIssue "2" @default.
• W1598053850 hasLocation W15980538501 @default.
• W1598053850 hasOpenAccess W1598053850 @default.
• W1598053850 hasPrimaryLocation W15980538501 @default.
• W1598053850 hasRelatedWork W147192326 @default.
• W1598053850 hasRelatedWork W172047007 @default.
• W1598053850 hasRelatedWork W2001590915 @default.
• W1598053850 hasRelatedWork W2045337689 @default.
• W1598053850 hasRelatedWork W2069812592 @default.
• W1598053850 hasRelatedWork W2071799308 @default.
• W1598053850 hasRelatedWork W2076757646 @default.
• W1598053850 hasRelatedWork W2089861464 @default.
• W1598053850 hasRelatedWork W261445698 @default.

• next