Matches in SemOpenAlex for { <https://semopenalex.org/work/W1598121712> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1598121712 abstract "Doxylamine succinate, a commonly used antihistamine, was administered as an admixture in the feed to groups of male and female B6C3F1 mice at dosage levels of 0,190,375, and 750 parts per million (ppm) (based on free amine) for 65 weeks (12 per group) or 2 years (48 per group). Survival to terminal sacrifice in the 2-year groups was 85–98% with no significant differences between groups of the same sex. Final body weights of the highest dose group were 3.4% and 8.7% less than controls in males and females, respectively. Doxylamine produced liver lesions in male mice including hepatocellular hypertrophy, atypical hepatocytes, clear cell and mixed cell foci, and necrosis. In females, doxylamine produced liver fatty change, hepatocellular hypertrophy, and necrosis. Doxylamine produced a significant increase in hepatocellular adenomas in the mid- and high-dosage groups of males and in the high-dosage group of females. Thyroid follicular cell hyperplasia and thyroid follicular cell adenomas also were increased in treated mice of both sexes. A treatment-related increase in cytoplasmic alteration of the parotid salivary gland in males and an increased incidence in hyperplasia of the pituitary gland in females were observed." @default.
- W1598121712 created "2016-06-24" @default.
- W1598121712 creator A5027579037 @default.
- W1598121712 creator A5090672063 @default.
- W1598121712 date "1993-08-01" @default.
- W1598121712 modified "2023-09-26" @default.
- W1598121712 title "Two-Year Toxicity Study of Doxylamine Succinate in B6C3F1 Mice" @default.
- W1598121712 cites W1966448777 @default.
- W1598121712 cites W1966864081 @default.
- W1598121712 cites W1996938959 @default.
- W1598121712 cites W2001329246 @default.
- W1598121712 cites W2014433035 @default.
- W1598121712 cites W2019040788 @default.
- W1598121712 cites W2026221924 @default.
- W1598121712 cites W2033375723 @default.
- W1598121712 cites W2038516058 @default.
- W1598121712 cites W2045295079 @default.
- W1598121712 cites W2053813431 @default.
- W1598121712 cites W2058495576 @default.
- W1598121712 cites W2071885509 @default.
- W1598121712 cites W2090013479 @default.
- W1598121712 cites W2093758246 @default.
- W1598121712 cites W2094941501 @default.
- W1598121712 cites W2129608685 @default.
- W1598121712 cites W2135798900 @default.
- W1598121712 cites W2164467062 @default.
- W1598121712 doi "https://doi.org/10.1177/109158189301200401" @default.
- W1598121712 hasPublicationYear "1993" @default.
- W1598121712 type Work @default.
- W1598121712 sameAs 1598121712 @default.
- W1598121712 citedByCount "7" @default.
- W1598121712 countsByYear W15981217122012 @default.
- W1598121712 countsByYear W15981217122018 @default.
- W1598121712 crossrefType "journal-article" @default.
- W1598121712 hasAuthorship W1598121712A5027579037 @default.
- W1598121712 hasAuthorship W1598121712A5090672063 @default.
- W1598121712 hasConcept C126322002 @default.
- W1598121712 hasConcept C134018914 @default.
- W1598121712 hasConcept C167414201 @default.
- W1598121712 hasConcept C2776880894 @default.
- W1598121712 hasConcept C2777562237 @default.
- W1598121712 hasConcept C2778057883 @default.
- W1598121712 hasConcept C29730261 @default.
- W1598121712 hasConcept C2992672570 @default.
- W1598121712 hasConcept C503630168 @default.
- W1598121712 hasConcept C526584372 @default.
- W1598121712 hasConcept C71924100 @default.
- W1598121712 hasConcept C98274493 @default.
- W1598121712 hasConceptScore W1598121712C126322002 @default.
- W1598121712 hasConceptScore W1598121712C134018914 @default.
- W1598121712 hasConceptScore W1598121712C167414201 @default.
- W1598121712 hasConceptScore W1598121712C2776880894 @default.
- W1598121712 hasConceptScore W1598121712C2777562237 @default.
- W1598121712 hasConceptScore W1598121712C2778057883 @default.
- W1598121712 hasConceptScore W1598121712C29730261 @default.
- W1598121712 hasConceptScore W1598121712C2992672570 @default.
- W1598121712 hasConceptScore W1598121712C503630168 @default.
- W1598121712 hasConceptScore W1598121712C526584372 @default.
- W1598121712 hasConceptScore W1598121712C71924100 @default.
- W1598121712 hasConceptScore W1598121712C98274493 @default.
- W1598121712 hasLocation W15981217121 @default.
- W1598121712 hasOpenAccess W1598121712 @default.
- W1598121712 hasPrimaryLocation W15981217121 @default.
- W1598121712 hasRelatedWork W1443228809 @default.
- W1598121712 hasRelatedWork W1966864081 @default.
- W1598121712 hasRelatedWork W1967698962 @default.
- W1598121712 hasRelatedWork W1972930599 @default.
- W1598121712 hasRelatedWork W1979350815 @default.
- W1598121712 hasRelatedWork W2008841847 @default.
- W1598121712 hasRelatedWork W2028064159 @default.
- W1598121712 hasRelatedWork W2033375723 @default.
- W1598121712 hasRelatedWork W2045695953 @default.
- W1598121712 hasRelatedWork W2068611298 @default.
- W1598121712 hasRelatedWork W2071885509 @default.
- W1598121712 hasRelatedWork W2074126751 @default.
- W1598121712 hasRelatedWork W2075805157 @default.
- W1598121712 hasRelatedWork W2078618136 @default.
- W1598121712 hasRelatedWork W2082508602 @default.
- W1598121712 hasRelatedWork W2141370561 @default.
- W1598121712 hasRelatedWork W2144396928 @default.
- W1598121712 hasRelatedWork W2163778938 @default.
- W1598121712 hasRelatedWork W2320558151 @default.
- W1598121712 hasRelatedWork W840856879 @default.
- W1598121712 isParatext "false" @default.
- W1598121712 isRetracted "false" @default.
- W1598121712 magId "1598121712" @default.
- W1598121712 workType "article" @default.