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- W1598287767 abstract "The effects of high hydrostatic pressure on the structure and biological activity of infectious bursal disease virus (IBDV), a commercially important pathogen of chickens, were investigated. IBDV was completely dissociated into subunits at a pressure of 240 MPa and 0 degrees C revealed by the change in intrinsic fluorescence spectrum and light scattering. The dissociation of IBDV showed abnormal concentration dependence as observed for some other viruses. Electron microscopy study showed that morphology of IBDV had an obvious change after pressure treatment at 0 degrees C. It was found that elevating pressure destroyed the infectivity of IBDV, and a completely pressure-inactivated IBDV could be obtained under proper conditions. The pressure-inactivated IBDV retained the original immunogenic properties and could elicit high titers of virus neutralizing antibodies. These results indicate that hydrostatic pressure provides a potential physical means to prepare antiviral vaccine." @default.
- W1598287767 created "2016-06-24" @default.
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- W1598287767 date "2000-07-01" @default.
- W1598287767 modified "2023-09-25" @default.
- W1598287767 title "Effects of hydrostatic pressure on the structure and biological activity of infectious bursal disease virus" @default.
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- W1598287767 doi "https://doi.org/10.1046/j.1432-1327.2000.01496.x" @default.
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