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- W1598343822 abstract "We have investigated why the recycling of eIF-2·GDP to eIF-2·GTP, mediated by the guanine nucleotide exchange factor eIF-2B, is rapid in rabbit reticulocyte lysate, reconstituted for optimal protein synthesis, but slow in an isolated reaction with purified eIF-2B. We have found that purified eIF-2B dissociates eIF-2·[3H]GDP as efficiently in the presence of GTP as it does in the presence of GDP provided Met-tRNAfMet is added. tRNAfMed is ineffective, and there is no Met-tRNAfMet requirement for exchange with GDP. Exchange of eIF-2 bound GDP for GTP is completely dependent upon Met-tRNAfMet in the presence of ATP, suggesting that under physiological conditions efficient recycling of eIF-2·GDP to eIF-2·GTP requires conversion of the latter, a relatively unstable complex, to a more stable Met-tRNAfMet·eIF-2·GTP complex." @default.
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- W1598343822 date "1991-12-01" @default.
- W1598343822 modified "2023-09-26" @default.
- W1598343822 title "The conversion of eIF-2·GDP to eIF-2·GTP by eIF-2B requires Met-tRNAfMet" @default.
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- W1598343822 doi "https://doi.org/10.1016/0006-291x(91)92109-w" @default.
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