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- W1598692308 abstract "The outcomes of stereotactic radiosurgery for arteriovenous malformations (AVMs) within or adjacent to the ventricular system are largely unknown. This study assessed the long-term outcomes and hemorrhage risks for patients with AVMs within this region who underwent Gamma Knife surgery (GKS) at the University of Pittsburgh.The authors retrospectively identified 188 patients with ventricular-region AVMs who underwent a single-stage GKS procedure during a 22-year interval. The median patient age was 32 years (range 3-80 years), the median target volume was 4.6 cm(3) (range 0.1-22 cm(3)), and the median marginal dose was 20 Gy (range 13-27 Gy).Arteriovenous malformation obliteration was confirmed by MRI or angiography in 89 patients during a median follow-up of 65 months (range 2-265 months). The actuarial rates of total obliteration were 32% at 3 years, 55% at 4 years, 60% at 5 years, and 64% at 10 years. Higher rates of AVM obliteration were obtained in the 26 patients with intraventricular AVMs. Twenty-five patients (13%) sustained a hemorrhage during the initial latency interval after GKS, indicating an annual hemorrhage rate of 3.4% prior to AVM obliteration. No patient experienced a hemorrhage after AVM obliteration was confirmed by imaging. Permanent neurological deficits due to adverse radiation effects developed in 7 patients (4%).Although patients in this study demonstrated an elevated hemorrhage risk that remained until complete obliteration, GKS still proved to be a generally safe and effective treatment for patients with these high-risk intraventricular and periventriclar AVMs." @default.
- W1598692308 created "2016-06-24" @default.
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- W1598692308 date "2014-12-01" @default.
- W1598692308 modified "2023-10-13" @default.
- W1598692308 title "Gamma Knife surgery for arteriovenous malformations within or adjacent to the ventricles" @default.
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- W1598692308 doi "https://doi.org/10.3171/2014.4.jns131943" @default.
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