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- W1598786205 abstract "3-O-β-D-Glucopyranosiduronyl-D-glucaro-1, 4-lactone (VI), a new masked inhibitor of β-glucuronidase, was synthesized by the fusion of dimethyl 2, 4-O-benzylidene-5-O-acetyl-D-glucarate (I) and methyl 1-bromo-1-deoxy-2, 3, 4-tri-O-acetyl-α-D-glucopyranuronate (II) in the presence of mercuric cyanide, followed by removal of the protecting groups and lactonization. The chemical structure of VI was confirmed to be 3-O-β-D-glucopyranosiduronyl-D-glucaro-1, 4-lactone from the chemical and physical data of the products (III, IV, V, and VI) obtained in the course of its synthesis. The inhibitory effect of VI on β-glucuronidase in vitro was also examined." @default.
- W1598786205 created "2016-06-24" @default.
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- W1598786205 date "1973-01-01" @default.
- W1598786205 modified "2023-09-27" @default.
- W1598786205 title "3-O-β-D-Glucopyranosiduronyl-D-glucaro-1, 4-lactone" @default.
- W1598786205 doi "https://doi.org/10.1248/cpb.21.1218" @default.
- W1598786205 hasPublicationYear "1973" @default.
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