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- W1598889259 abstract "Bronchopulmonary C-fibers (PCFs) play a key role in producing central apnea, especially the lethal ventilatory arrest during hypoxia (Xu, JAP 2003). We recently found that PNE sensitized PCFs and promoted central apnea and lethal ventilatory arrest during severe hypoxia (5% O2 for 60 min) in rat pus (EB 2013). Pulmonary SP and AD, and PCFs’ receptors (NK1R, 5-HT3R, ADA1R, TRPV1, and α7nAChR) are responsible for PCF sensitization/stimulation. Thus, we hypothesized that PNE would upregulate pulmonary SP and AD and these receptors in the nodose ganglia, contributing to the central apnea and lethal ventilatory arrest. In P11-14 rat pups, we analyzed inflammatory cells, SP, and AD in BALF and SP and gene expressions of NK1R, 5-HT3AR/3BR, ADA1R, TRPV1, and α7nAChR in the nodose ganglia. SP and AD were detected by ELISA and biosensors, respectively, and others by real-time PCR. Our results showed that PNE obviously increased total inflammatory cells primarily via raising microphages without change in SP and AD in BALF. PNE significantly increased SP and mRNA of NK1R, TRPV1 (all P < 0.05), and ADA1R (P = 0.06) with 5-HT3AR/3BR unchanged and α7nAChR undetectable in the nodose ganglia. Our results suggest that PNE is able to enhance inflammatory cells and NK1R, TRPV1, ADA1R and SP expressions in the nodose ganglia, likely contributing to the PNE-induced PCF sensitization/activation. Grant Funding Source: Supported by HL-107462" @default.
- W1598889259 created "2016-06-24" @default.
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- W1598889259 date "2014-04-01" @default.
- W1598889259 modified "2023-10-16" @default.
- W1598889259 title "Upregulation of substance P, neurokinin‐1 receptor, TRPV1, and adenosine A 1 R in nodose ganglia of rat pups treated with prenatal nicotinic exposure (713.5)" @default.
- W1598889259 doi "https://doi.org/10.1096/fasebj.28.1_supplement.713.5" @default.
- W1598889259 hasPublicationYear "2014" @default.
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