FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1598912670> ?p ?o ?g. }

• W1598912670 endingPage "2270" @default.
• W1598912670 startingPage "2263" @default.
• W1598912670 abstract "The glutamate analog, alpha-aminomethylglutaric acid, was synthetized by Michael addition of ammonia to 2-methylene glutaronitrile followed by hydrolysis of the intermediate alpha-aminomethylglutaryl nitrile; the analog cyclizes readily on heating to 2-piperidone-5-carboxylic acid. Sheep brain glutamine synthetase utilizes one isomer of DL-alpha-aminomethylglutarate at about 10% of the rate with L-glutamate. gamma-Glutamylcysteine synthetase uses both isomers of DL-alpha-aminomethylglutarate, preferentially acting on the same isomer used by glutamine synthetase. gamma-(alpha-Aminomethyl)glutaryl-alpha-aminobutyrate, prepared enzymatically with gamma-glutamylcysteine synthetase, was found to be a substrate and an inhibitor of glutathione synthetase. alpha-Aminomethylglutarate does not inhibit gamma-glutamyl cyclotransferase and gamma-glutamyl transpeptidase appreciably. When alpha-aminomethylglutarate was administered to mice, there were substantial decreases in the levels of glutamine, glutathione, glutamate, and glycine in the kidney, and of glutamine and glutamate in the liver, indicating that this glutamate analog is effective as an inhibitor of glutamine and glutathione synthesis in vivo, and suggesting that it may also inhibit other enzymes." @default.
• W1598912670 created "2016-06-24" @default.
• W1598912670 creator A5000178422 @default.
• W1598912670 creator A5028546151 @default.
• W1598912670 creator A5082707374 @default.
• W1598912670 date "1976-04-01" @default.
• W1598912670 modified "2023-09-28" @default.
• W1598912670 title "alpha-Aminomethylglutarate, a beta-amino analog of glutamate that interacts with glutamine synthetase and the enzymes that catalyze glutathione synthesis." @default.
• W1598912670 cites W1423235038 @default.
• W1598912670 cites W1535345009 @default.
• W1598912670 cites W1537487968 @default.
• W1598912670 cites W1557095374 @default.
• W1598912670 cites W1648994921 @default.
• W1598912670 cites W1841532588 @default.
• W1598912670 cites W1969423770 @default.
• W1598912670 cites W1972643843 @default.
• W1598912670 cites W1975066651 @default.
• W1598912670 cites W1975899947 @default.
• W1598912670 cites W1977400901 @default.
• W1598912670 cites W2004311740 @default.
• W1598912670 cites W2009434080 @default.
• W1598912670 cites W2009527472 @default.
• W1598912670 cites W2030360075 @default.
• W1598912670 cites W2033651371 @default.
• W1598912670 cites W2043322248 @default.
• W1598912670 cites W2048588519 @default.
• W1598912670 cites W2049398242 @default.
• W1598912670 cites W2050676294 @default.
• W1598912670 cites W2070274699 @default.
• W1598912670 cites W2071569995 @default.
• W1598912670 cites W2330539976 @default.
• W1598912670 cites W2410451741 @default.
• W1598912670 cites W2429006706 @default.
• W1598912670 cites W44397239 @default.
• W1598912670 doi "https://doi.org/10.1016/s0021-9258(17)33582-2" @default.
• W1598912670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4441" @default.
• W1598912670 hasPublicationYear "1976" @default.
• W1598912670 type Work @default.
• W1598912670 sameAs 1598912670 @default.
• W1598912670 citedByCount "8" @default.
• W1598912670 crossrefType "journal-article" @default.
• W1598912670 hasAuthorship W1598912670A5000178422 @default.
• W1598912670 hasAuthorship W1598912670A5028546151 @default.
• W1598912670 hasAuthorship W1598912670A5082707374 @default.
• W1598912670 hasBestOaLocation W15989126701 @default.
• W1598912670 hasConcept C159110408 @default.
• W1598912670 hasConcept C170493617 @default.
• W1598912670 hasConcept C181199279 @default.
• W1598912670 hasConcept C185592680 @default.
• W1598912670 hasConcept C191771488 @default.
• W1598912670 hasConcept C199360897 @default.
• W1598912670 hasConcept C2775944032 @default.
• W1598912670 hasConcept C2776174256 @default.
• W1598912670 hasConcept C2779289688 @default.
• W1598912670 hasConcept C2779349466 @default.
• W1598912670 hasConcept C41008148 @default.
• W1598912670 hasConcept C49453240 @default.
• W1598912670 hasConcept C515207424 @default.
• W1598912670 hasConcept C538909803 @default.
• W1598912670 hasConcept C55493867 @default.
• W1598912670 hasConcept C61174792 @default.
• W1598912670 hasConcept C64943373 @default.
• W1598912670 hasConcept C71924100 @default.
• W1598912670 hasConceptScore W1598912670C159110408 @default.
• W1598912670 hasConceptScore W1598912670C170493617 @default.
• W1598912670 hasConceptScore W1598912670C181199279 @default.
• W1598912670 hasConceptScore W1598912670C185592680 @default.
• W1598912670 hasConceptScore W1598912670C191771488 @default.
• W1598912670 hasConceptScore W1598912670C199360897 @default.
• W1598912670 hasConceptScore W1598912670C2775944032 @default.
• W1598912670 hasConceptScore W1598912670C2776174256 @default.
• W1598912670 hasConceptScore W1598912670C2779289688 @default.
• W1598912670 hasConceptScore W1598912670C2779349466 @default.
• W1598912670 hasConceptScore W1598912670C41008148 @default.
• W1598912670 hasConceptScore W1598912670C49453240 @default.
• W1598912670 hasConceptScore W1598912670C515207424 @default.
• W1598912670 hasConceptScore W1598912670C538909803 @default.
• W1598912670 hasConceptScore W1598912670C55493867 @default.
• W1598912670 hasConceptScore W1598912670C61174792 @default.
• W1598912670 hasConceptScore W1598912670C64943373 @default.
• W1598912670 hasConceptScore W1598912670C71924100 @default.
• W1598912670 hasIssue "8" @default.
• W1598912670 hasLocation W15989126701 @default.
• W1598912670 hasOpenAccess W1598912670 @default.
• W1598912670 hasPrimaryLocation W15989126701 @default.
• W1598912670 hasRelatedWork W141026042 @default.
• W1598912670 hasRelatedWork W1535914835 @default.
• W1598912670 hasRelatedWork W1577354833 @default.
• W1598912670 hasRelatedWork W1608569125 @default.
• W1598912670 hasRelatedWork W1712989564 @default.
• W1598912670 hasRelatedWork W1725499016 @default.
• W1598912670 hasRelatedWork W1864249421 @default.
• W1598912670 hasRelatedWork W1988929832 @default.
• W1598912670 hasRelatedWork W2388156795 @default.
• W1598912670 hasRelatedWork W418417307 @default.
• W1598912670 hasVolume "251" @default.
• W1598912670 isParatext "false" @default.
• W1598912670 isRetracted "false" @default.

• next