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- W1598943986 abstract "Sex determination and differentiation are distinct, consecutive processes that follow the establishment of chromosomal sex at the time of fertilization. The term “sex determination” refers to the development of gonadal sex—a process that occurs at approximately 6–7 weeks’ gestation in the human male fetus, and around 10–11 weeks’ gestation in the female fetus. Male sex determination is synonymous with testis determination. This process (alternatively called primary sex differentiation) results from a coordinated series of exquisitely regulated, but as yet incompletely understood, events. As generally used, the term “sex differentiation,” refers to the processes downstream of gonadal development—the processes that are regulated by gonadal secretions or lack thereof (also called secondary sex differentiation). In essence, the sex chromosome complement endowed at fertilization determines gonad type and the latter determines the pattern of differentiation seen in the genital ducts and external genitalia." @default.
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- W1598943986 date "1998-01-01" @default.
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- W1598943986 title "Disorders of Sex Determination and Differentiation" @default.
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- W1598943986 doi "https://doi.org/10.1007/978-1-59259-726-0_57" @default.
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