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- W1598981490 abstract "Background Azapirones are a group of drugs that work at the 5‐HT1A receptor and are used to treat patients suffering from generalized anxiety disorder (GAD). However, several studies have shown conflicting results. Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered. Objectives To assess the efficacy and the acceptability of azapirones for the treatment of GAD. Search methods Initiallyt the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register (CCDANCTR) and The Cochrane Central Register of Controlled Trials (CENTRAL) were searched, incorporating results of group searches of MEDLINE (1966 to June 2005), EMBASE (1980 to June 2005), CINAHL (1982 to June 2005), PsycLIT (1974 to June 2005), PSYNDEX (1977 to June 2005), and LILACS (1982 to June 2005). Subsequently the revised Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Registers (CCDANCTR‐Studies and CCDANCTR‐References) were searched on 21‐10‐2005. Reference lists of relevant papers and major text books of anxiety disorder were examined. Authors, other experts in the field and pharmaceutical companies were contacted for knowledge of suitable trials, published or unpublished. Specialist journals concerning azapirones were handsearched. Selection criteria Randomized controlled trials of azapirones, including buspirone versus placebo and/or other medication and/or psychological treatment, were included. Participants were males and females of all ages with a diagnosis of generalized anxiety disorder. Data collection and analysis Data were extracted from the original reports independently by CC, MA and MT. The main outcomes studied were related to the objectives stated above. Data were analysed for generalized anxiety disorder versus placebo, versus other medication and versus psychological treatment separately. Data were analysed using Review Manager Version 4.2.7. Main results Thirty six trials were included in the review, reporting on 5908 participants randomly allocated to azapirones and/or placebo, benzodiazepines, antidepressants, psychotherapy or kava kava. Azapirones, including buspirone, were superior to placebo in treating GAD. The calculated number needed to treat for azapirones using the Clinical Global Impression scale was 4.4 (95% confidence interval (CI) 2.16 to 15.4). Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants, kava kava or psychotherapy. Azapirones appeared to be well tolerated. Fewer participants stopped taking benzodiazepines compared to azapirones. The length of studies ranged from four to nine weeks, with one study lasting 14 weeks. Authors' conclusions Azapirones appeared to be useful in the treatment of GAD, particularly for those participants who had not been on a benzodiazepine. Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines. Side effects appeared mild and non serious in the azapirone treated group. Longer term studies are needed to show that azapirones are effective in treating GAD, which is a chronic long‐term illness." @default.
- W1598981490 created "2016-06-24" @default.
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- W1598981490 date "2006-07-19" @default.
- W1598981490 modified "2023-09-23" @default.
- W1598981490 title "Azapirones for generalized anxiety disorder" @default.
- W1598981490 cites W131002439 @default.
- W1598981490 cites W133794067 @default.
- W1598981490 cites W143725865 @default.
- W1598981490 cites W1499454018 @default.
- W1598981490 cites W1553691067 @default.
- W1598981490 cites W1591259115 @default.
- W1598981490 cites W163879605 @default.
- W1598981490 cites W166264177 @default.
- W1598981490 cites W191202430 @default.
- W1598981490 cites W192226528 @default.
- W1598981490 cites W1964435673 @default.
- W1598981490 cites W1971292668 @default.
- W1598981490 cites W1975637480 @default.
- W1598981490 cites W1975806198 @default.
- W1598981490 cites W1977542249 @default.
- W1598981490 cites W1978718865 @default.
- W1598981490 cites W1981776119 @default.
- W1598981490 cites W1984208027 @default.
- W1598981490 cites W1990408097 @default.
- W1598981490 cites W1994901395 @default.
- W1598981490 cites W1996278546 @default.
- W1598981490 cites W2001245370 @default.
- W1598981490 cites W2005720665 @default.
- W1598981490 cites W2010095953 @default.
- W1598981490 cites W2018764502 @default.
- W1598981490 cites W2021660015 @default.
- W1598981490 cites W2022276674 @default.
- W1598981490 cites W2024264511 @default.
- W1598981490 cites W2025181023 @default.
- W1598981490 cites W2027104154 @default.
- W1598981490 cites W2027352968 @default.
- W1598981490 cites W2030432644 @default.
- W1598981490 cites W2030825411 @default.
- W1598981490 cites W2037875799 @default.
- W1598981490 cites W2040537436 @default.
- W1598981490 cites W2042605575 @default.
- W1598981490 cites W2059637464 @default.
- W1598981490 cites W2063980879 @default.
- W1598981490 cites W2065747869 @default.
- W1598981490 cites W2075676284 @default.
- W1598981490 cites W2083339227 @default.
- W1598981490 cites W2089270788 @default.
- W1598981490 cites W2092760765 @default.
- W1598981490 cites W2101594550 @default.
- W1598981490 cites W2105511769 @default.
- W1598981490 cites W2108445396 @default.
- W1598981490 cites W2118225566 @default.
- W1598981490 cites W2129632383 @default.
- W1598981490 cites W2135917232 @default.
- W1598981490 cites W2151361778 @default.
- W1598981490 cites W2159061031 @default.
- W1598981490 cites W2160070901 @default.
- W1598981490 cites W2257473181 @default.
- W1598981490 cites W2324278286 @default.
- W1598981490 cites W2333364921 @default.
- W1598981490 cites W2396292784 @default.
- W1598981490 cites W2398513805 @default.
- W1598981490 cites W2402118362 @default.
- W1598981490 cites W2404628158 @default.
- W1598981490 cites W2408508337 @default.
- W1598981490 cites W2410131167 @default.
- W1598981490 cites W2413143221 @default.
- W1598981490 cites W2414971391 @default.
- W1598981490 cites W2431634655 @default.
- W1598981490 cites W2441912175 @default.
- W1598981490 cites W2464558581 @default.
- W1598981490 cites W2606791358 @default.
- W1598981490 cites W338696411 @default.
- W1598981490 cites W4254339345 @default.
- W1598981490 cites W4254804094 @default.
- W1598981490 cites W4301751484 @default.
- W1598981490 cites W76596067 @default.
- W1598981490 doi "https://doi.org/10.1002/14651858.cd006115" @default.
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