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- W1599147334 abstract "Strategies to enhance the efficacy of DNA vaccination against malignancy remain to be established. In this study, plasmids expressing tumor antigen incorporated into the signal peptide of human IL-2 were tested as DNA vaccine in murine model system. Results showed that antigen-specific CTL responses were elicited by intramuscular injection of these plasmids. Importantly, compared with minigene vector expressing the same epitope, the antigen epitope-incorporated, IL-2 expression plasmid vaccination was more effective in protecting mice from antigen-expressing tumor challenge. The improved efficacy appears to result from enhanced antigen presentation as well as the immunostimulatory activity of IL-2. This approach may provide new perspectives in designing cytokine-adjuvant DNA vaccines for clinical applications." @default.
- W1599147334 created "2016-06-24" @default.
- W1599147334 date "2004-05-01" @default.
- W1599147334 modified "2023-10-18" @default.
- W1599147334 title "Antigen Epitope-Expressing Cytokines for DNA Immunization" @default.
- W1599147334 doi "https://doi.org/10.1016/j.ymthe.2004.06.203" @default.
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