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• W1599178081 abstract "Resume Objectif : Decrire un cas d’ hyperemesis gravidarum refractaire aux traitements standards dont l’etat de sante s’est ameliore a la suite de la prise de clonidine par voie orale. Resume du cas : Il s’agit d’une femme de 32 ans souffrant de vomissements depuis le debut de sa grossesse. L’aggravation de son etat de sante a necessite son hospitalisation a 14 semaines de grossesse. Les vomissements s’accompagnaient d’une hypersalivation, d’une epigastralgie, d’une perte de poids, d’une cetonurie et d’une hypokaliemie, ce qui a permis de poser un diagnostic d’ hyperemesis gravidarum . Plusieurs traitements ont ete entrepris pour soulager les symptomes : hydratation, pyridoxine, diphenhydramine, metoclopramide, ranitidine, pantoprazole et ondansetron. Finalement, l’ajout de la clonidine orale a permis d’obtenir un soulagement important et durable des symptomes d’ hyperemesis gravidarum . Discussion : L’ hyperemesis gravidarum complique jusqu’a 2 % des grossesses. Il est possible de recourir a plusieurs medicaments dans cette indication, mais certaines patientes ne repondent pas aux traitements habituels. La clonidine est un agoniste alphaadrenergique central principalement utilise comme antihypertenseur. Peu de donnees de la litterature scientifique appuient son utilisation pour le traitement de l’ hyperemesis gravidarum refractaire. D’un point de vue chronologique et clinique, on peut considerer comme probable l’efficacite de la clonidine pour le soulagement de l’ hyperemesis gravidarum dans le cas presente ici. Conclusion : Ce rapport de cas decrit l’utilisation de la clonidine pour une patiente refractaire aux traitements standards. L’efficacite de cet agent devra etre evaluee dans le cadre d’etudes cliniques pour mieux etablir sa place dans la therapie. Abstract Objective: To describe a case of standard treatment–refractory hyperemesis gravidarum in which the patient’s condition improved following the administration of oral clonidine. Case summary: A pregnant 32-year-old woman was admitted to hospital at 14 weeks’ gestation. She was vomiting, with hypersalivation, epigastralgia, weight loss, ketonuria and hypokalemia, leading to a diagnosis of hyperemesis gravidarum. Several treatments were used to relieve the symptoms: hydration, pyridoxine, diphenhydramine, metoclopramide, ranitidine, pantoprazole, and ondansetron. Finally, oral clonidine was prescribed, resulting in the patient’s significant and lasting symptomatic relief from hyperemesis gravidarum. Discussion: Hyperemesis gravidarum is a complication of pregnancy in up to 2% of cases. A number of drugs can be used for this condition, but some patients do not respond to the usual treatment. Clonidine is a central alphaadrenergic agonist used mainly as an antihypertensive. Limited data exist in the scientific literature to support its use in the treatment of refractory hyperemesis gravidarum. From a chronological and clinical standpoint, clonidine was effective in relieving hyperemesis gravidarum in this patient. Conclusion: This case report describes the use of clonidine in a patient with hyperemesis gravidarum that was refractory to standard treatment. The efficacy of this agent should be evaluated in clinical trials to better determine its therapeutic role." @default.
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• W1599178081 date "2014-12-28" @default.
• W1599178081 modified "2023-09-24" @default.
• W1599178081 title "Traitement à la clonidine par voie orale pour une patiente atteinte d’hyperemesis gravidarum réfractaire" @default.
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