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- W1599201937 abstract "Peak detection is a central problem in genomic data analysis, and current algorithms for this task are unsupervised and mostly effective for a single data type and pattern (e.g. H3K4me3 data with a sharp peak pattern). We propose PeakSeg, a new constrained maximum likelihood segmentation model for peak detection with an efficient inference algorithm: constrained dynamic programming. We investigate unsupervised and supervised learning of penalties for the critical model selection problem. We show that the supervised method has state-of-the-art peak detection across all data sets in a benchmark that includes both sharp H3K4me3 and broad H3K36me3 patterns." @default.
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- W1599201937 date "2015-01-01" @default.
- W1599201937 modified "2023-10-01" @default.
- W1599201937 title "PeakSeg: constrained optimal segmentation and supervised penalty learning for peak detection in count data" @default.
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