FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1599415696> ?p ?o ?g. }

• W1599415696 endingPage "1818" @default.
• W1599415696 startingPage "1805" @default.
• W1599415696 abstract "BACKGROUND AND PURPOSE The combination of Chinese herbs, Astragali Radix and Angelicae Sinensis Radix, could alleviate renal interstitial fibrosis. Astragaloside IV (AS‐IV) and ferulic acid (FA) are the two major active constituents in this combination. In this study, we employed rats with unilateral ureteral obstruction to determine whether AS‐IV and FA have the same renoprotective effects and investigated the mechanisms of this action. EXPERIMENTAL APPROACH Renal pathological changes were evaluated after treatment with AS‐IV, FA or AS‐IV + FA ( AF ) for 10 days. Meanwhile, the expression of transforming growth factor β 1 (TGF‐β 1 ), fibronectin, α‐smooth muscle actin (α‐SMA), phosphorylation of c‐Jun NH 2 ‐terminal kinase (p‐JNK) and nitric oxide (NO) production in kidney were determined. The expressions of fibronectin, α‐SMA, mitogen‐activated protein kinases [JNK, extracellular signal‐regulated kinases (ERK), P38] in TGF‐β 1 ‐treated NRK‐49F cells or interleukin‐1‐treated HK‐2 cells after AS‐IV, FA or AF were assessed. KEY RESULTS AF alleviated the infiltration of mononuclear cells, tubular atrophy and interstitial fibrosis; reduced the expression of fibronectin, α‐SMA, TGF‐β 1 and p‐JNK; and dramatically increased the production of NO in obstructed kidneys. Neither AS‐IV nor FA alone improved renal damage, but both increased NO production. AF inhibited α‐SMA and fibronectin expression in NRK‐49F or HK‐2 cells. Furthermore, AF significantly inhibited IL‐1β‐induced JNK phosphorylation, without affecting ERK or P38 phosphorylation. Neither AS‐IV nor FA alone had any effect on the cells. CONCLUSIONS AND IMPLICATIONS AS‐IV synergizes with FA to alleviate renal tubulointerstitial fibrosis; this was associated with inhibition of tubular epithelial–mesenchymal transdifferentiation (EMT) and fibroblast activation, as well as an increase in NO production in the kidney." @default.
• W1599415696 created "2016-06-24" @default.
• W1599415696 creator A5009020573 @default.
• W1599415696 creator A5009570442 @default.
• W1599415696 creator A5010111572 @default.
• W1599415696 creator A5030229711 @default.
• W1599415696 creator A5043565162 @default.
• W1599415696 creator A5049755294 @default.
• W1599415696 creator A5066341237 @default.
• W1599415696 creator A5072495806 @default.
• W1599415696 creator A5075545173 @default.
• W1599415696 creator A5085554736 @default.
• W1599415696 date "2011-03-22" @default.
• W1599415696 modified "2023-10-17" @default.
• W1599415696 title "Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy" @default.
• W1599415696 cites W1963694975 @default.
• W1599415696 cites W1968181318 @default.
• W1599415696 cites W1969393277 @default.
• W1599415696 cites W1975277514 @default.
• W1599415696 cites W1994101634 @default.
• W1599415696 cites W1998771541 @default.
• W1599415696 cites W2003246834 @default.
• W1599415696 cites W2017089487 @default.
• W1599415696 cites W2020181808 @default.
• W1599415696 cites W2023848963 @default.
• W1599415696 cites W2027739139 @default.
• W1599415696 cites W2028112576 @default.
• W1599415696 cites W2029242493 @default.
• W1599415696 cites W2033766409 @default.
• W1599415696 cites W2038822864 @default.
• W1599415696 cites W2049135967 @default.
• W1599415696 cites W2049384286 @default.
• W1599415696 cites W2049533449 @default.
• W1599415696 cites W2053785572 @default.
• W1599415696 cites W2054028666 @default.
• W1599415696 cites W2057259387 @default.
• W1599415696 cites W2059988766 @default.
• W1599415696 cites W2060308583 @default.
• W1599415696 cites W2061285226 @default.
• W1599415696 cites W2064732442 @default.
• W1599415696 cites W2067459476 @default.
• W1599415696 cites W2067924741 @default.
• W1599415696 cites W2070005444 @default.
• W1599415696 cites W2074276224 @default.
• W1599415696 cites W2075092913 @default.
• W1599415696 cites W2078044852 @default.
• W1599415696 cites W2078145959 @default.
• W1599415696 cites W2078657995 @default.
• W1599415696 cites W2091310109 @default.
• W1599415696 cites W2091875435 @default.
• W1599415696 cites W2093675035 @default.
• W1599415696 cites W2101766543 @default.
• W1599415696 cites W2102633875 @default.
• W1599415696 cites W2106075253 @default.
• W1599415696 cites W2106256269 @default.
• W1599415696 cites W2121458082 @default.
• W1599415696 cites W2126798954 @default.
• W1599415696 cites W2127224804 @default.
• W1599415696 cites W2132803823 @default.
• W1599415696 cites W2132990943 @default.
• W1599415696 cites W2133011097 @default.
• W1599415696 cites W2149398393 @default.
• W1599415696 cites W2154742224 @default.
• W1599415696 cites W2171095755 @default.
• W1599415696 cites W2318343874 @default.
• W1599415696 cites W2413338154 @default.
• W1599415696 cites W4250731522 @default.
• W1599415696 doi "https://doi.org/10.1111/j.1476-5381.2011.01206.x" @default.
• W1599415696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081123" @default.
• W1599415696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21232035" @default.
• W1599415696 hasPublicationYear "2011" @default.
• W1599415696 type Work @default.
• W1599415696 sameAs 1599415696 @default.
• W1599415696 citedByCount "57" @default.
• W1599415696 countsByYear W15994156962012 @default.
• W1599415696 countsByYear W15994156962013 @default.
• W1599415696 countsByYear W15994156962014 @default.
• W1599415696 countsByYear W15994156962015 @default.
• W1599415696 countsByYear W15994156962016 @default.
• W1599415696 countsByYear W15994156962017 @default.
• W1599415696 countsByYear W15994156962018 @default.
• W1599415696 countsByYear W15994156962019 @default.
• W1599415696 countsByYear W15994156962020 @default.
• W1599415696 countsByYear W15994156962021 @default.
• W1599415696 countsByYear W15994156962022 @default.
• W1599415696 countsByYear W15994156962023 @default.
• W1599415696 crossrefType "journal-article" @default.
• W1599415696 hasAuthorship W1599415696A5009020573 @default.
• W1599415696 hasAuthorship W1599415696A5009570442 @default.
• W1599415696 hasAuthorship W1599415696A5010111572 @default.
• W1599415696 hasAuthorship W1599415696A5030229711 @default.
• W1599415696 hasAuthorship W1599415696A5043565162 @default.
• W1599415696 hasAuthorship W1599415696A5049755294 @default.
• W1599415696 hasAuthorship W1599415696A5066341237 @default.
• W1599415696 hasAuthorship W1599415696A5072495806 @default.
• W1599415696 hasAuthorship W1599415696A5075545173 @default.
• W1599415696 hasAuthorship W1599415696A5085554736 @default.
• W1599415696 hasBestOaLocation W15994156962 @default.

• next