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• W1599453670 abstract "Summary Background: Normovolemic hemodilution (HD) in adult animal studies has shown exacerbation of traumatic brain injury (TBI) lesion volumes. Similar studies in juvenile rats have not been reported and outcomes are likely to be different. This study investigated the effects of normovolemic hemodilution (21% hematocrit) in a juvenile TBI (jTBI) model. Methods: Twenty 17‐day‐old rats underwent moderate cortical contusion impact injury (CCI) and were divided into four groups: CCI/hemodilution (HD) (group HD), CCI/no HD (group C), Sham/HD (group SHD), and Sham/no HD (group S). Regional laser Doppler flowmetry (LDF), edema formation (MRI‐T2WI), water mobility assessed using diffusion weighted imaging (MRI‐DWI), open field activity tests, and histological analyses were evaluated for lesion characteristics. Results: Hemodilution significantly increased blood flow in the HD compared to the C group after TBI. T2WI revealed a significantly increased extravascular blood volume in HD at 1, 7, and 14 days post‐CCI. Edematous tissue and total contusional lesion volume were higher in HD‐treated animals at 1 and 14 days. DWI revealed that HD, SHD, and C groups had elevated water mobility compared to S groups in the ipsilateral cortex and striatum. Histology showed a larger cortical lesion in the C than HD group. Open field activity was increased in HD, C, and SHD groups compared to the S group. Conclusions: Hemodilution results in significant brain hyperemia with increased edema formation, extravascular blood volume, and water mobility after jTBI. Hemodilution results in less cortical damage but did not alter behavior. Hemodilution is likely not to be clinically beneficial following jTBI." @default.
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• W1599453670 date "2011-09-20" @default.
• W1599453670 modified "2023-10-16" @default.
• W1599453670 title "Effects of hemodilution after traumatic brain injury in juvenile rats" @default.
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• W1599453670 cites W1964919195 @default.
• W1599453670 cites W1966668848 @default.
• W1599453670 cites W1967254006 @default.
• W1599453670 cites W1971938856 @default.
• W1599453670 cites W1974339392 @default.
• W1599453670 cites W1974633644 @default.
• W1599453670 cites W1975708468 @default.
• W1599453670 cites W1976839120 @default.
• W1599453670 cites W1977043408 @default.
• W1599453670 cites W1986142021 @default.
• W1599453670 cites W1991481781 @default.
• W1599453670 cites W1992617791 @default.
• W1599453670 cites W1995137913 @default.
• W1599453670 cites W1996125369 @default.
• W1599453670 cites W1998183747 @default.
• W1599453670 cites W2004065438 @default.
• W1599453670 cites W2008245435 @default.
• W1599453670 cites W20087376 @default.
• W1599453670 cites W2010825035 @default.
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• W1599453670 cites W2014520459 @default.
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• W1599453670 cites W2021702487 @default.
• W1599453670 cites W2023775209 @default.
• W1599453670 cites W2028792230 @default.
• W1599453670 cites W2031244297 @default.
• W1599453670 cites W2038029389 @default.
• W1599453670 cites W2043411185 @default.
• W1599453670 cites W2050339045 @default.
• W1599453670 cites W2059580477 @default.
• W1599453670 cites W2063202138 @default.
• W1599453670 cites W2064857678 @default.
• W1599453670 cites W2065384002 @default.
• W1599453670 cites W2067954619 @default.
• W1599453670 cites W2069019831 @default.
• W1599453670 cites W2071979043 @default.
• W1599453670 cites W2079723326 @default.
• W1599453670 cites W2086399377 @default.
• W1599453670 cites W2093126739 @default.
• W1599453670 cites W2093133693 @default.
• W1599453670 cites W2093584282 @default.
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• W1599453670 cites W2114926797 @default.
• W1599453670 cites W2120086067 @default.
• W1599453670 cites W2124894530 @default.
• W1599453670 cites W2138303552 @default.
• W1599453670 cites W2141298232 @default.
• W1599453670 cites W2143682435 @default.
• W1599453670 cites W2143837759 @default.
• W1599453670 cites W2147915724 @default.
• W1599453670 cites W2155921648 @default.
• W1599453670 cites W2156870897 @default.
• W1599453670 cites W2158519478 @default.
• W1599453670 cites W2168435319 @default.
• W1599453670 cites W2219229579 @default.
• W1599453670 cites W2220349982 @default.
• W1599453670 cites W2318263005 @default.
• W1599453670 cites W4239038106 @default.
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• W1599453670 doi "https://doi.org/10.1111/j.1460-9592.2011.03695.x" @default.
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