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- W1599611024 abstract "The immunosuppressive alpha globulin (Fraction C) extracted from bovine thymus has been compared to bovine serum Fraction C and found to be similar with regard to effects on phytohemagglutinin-induced blast cell transformation, on synthetic events in stimulated cells, and on the generation of macrophage migration inhibitory factor (MIF). Fraction C does not prevent blast cell transformation, and is still capable of profound anti-proliferative effects as measured by DNA synthetic rates when added to lymphocytes already stimulated for 24 hr with PHA. RNA synthesis, on the other hand, is quantitatively normal, while protein and membrane phospholipid synthetic rates can be normal or depressed. Furthermore, the generation of MIF by peritoneal exudate cells of tuberculin-sensitized guinea pigs in the presence of antigen is not blocked by large doses of Fraction C. It is concluded that this partially purified natural globulin exerts its modulating effect on immune responses by preventing new DNA synthesis in the stimulated cell and not by blocking the early recognition or response to antigen." @default.
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- W1599611024 date "1971-10-01" @default.
- W1599611024 modified "2023-09-27" @default.
- W1599611024 title "Immunosuppressive alpha globulin from bovine thymus" @default.
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- W1599611024 doi "https://doi.org/10.1016/0008-8749(71)90054-2" @default.
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