Matches in SemOpenAlex for { <https://semopenalex.org/work/W1599639232> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1599639232 abstract "Background: Intravenous Tissue Plasminogen Activator (TPA) is the only FDA approved medical therapy for acute ischemic stroke (AIS). Prior study suggests that early recanalization is associated with better stroke outcome. Our aim was to correlate task-negative and task-positive (TN/TP) resting state network activity with tissue perfusion and functional outcome, in stroke patients who received TPA. Method: AIS patients were consented and underwent NIH stroke scale (NIHSS) assessment and magnetic resonance imaging (MRI) scans during TPA infusion (baseline) and six hours post stroke. The MRI sequences include contrast-enhanced perfusion weighted image (PWI) and resting state Blood Oxygen Level-Dependent or BOLD (RSB) images acquired using a Siemens Treo 3T MRI scanner. Additionally, the RSB scan and the NIHSS were obtained at a 30-day follow up visit. Results: Fourteen patients (mean age ± SD=63 ±14, 50% male, 50% white, 43% black and 7% others) who qualified for TPA completed the study at baseline and 6 hours post stroke. Of these, 6 patients had valid follow up data at 30 days. Three patients without cerebral ischemia were excluded. A paired samples t-test comparing baseline and 6h post stroke showed a significantly improved TP network t(10)= -4.24 p< 0.05. The resting network connectivity improved from 6 hours post stroke to 30-days follow up, t(5)= -5.35 p< 0.01. Similarly, NIHSS, at 6h post stroke t(10)= 3.62 p< 0.01 and at 30-days follow up t(5)= -3.4 p< 0.01 were significantly better than the NIHSS at baseline. The 6-hours post-stroke perfusion correlated with the resting network connectivity in both the damaged (r=-0.56 p= 0.07) and intact hemispheres (r= -0.57 p= 0.06). Differences in functional connectivity and NIHSS scores from baseline to 6 h were positively correlated (r= 0.56 p=0.07). Conclusion: In this pilot study we found that TPA led to changes in MRI based resting state networks and associated functional outcome. Correlations were found between perfusion, functional connectivity and NIHSS. This suggests that the improvement of resting state network means improved efficiency of brain activity indicated by functional outcome and may be a potential predictive MRI biomarker for TPA response. A larger study is needed to verify this finding." @default.
- W1599639232 created "2016-06-24" @default.
- W1599639232 creator A5004519450 @default.
- W1599639232 creator A5012581799 @default.
- W1599639232 creator A5018286707 @default.
- W1599639232 creator A5020029507 @default.
- W1599639232 creator A5038140733 @default.
- W1599639232 creator A5048090321 @default.
- W1599639232 creator A5062109811 @default.
- W1599639232 creator A5076080475 @default.
- W1599639232 date "2015-02-01" @default.
- W1599639232 modified "2023-09-26" @default.
- W1599639232 title "Abstract W P29: Tissue Plasminogen Activator Mediated Reperfusion, and Subsequent Improvement in Resting State Connectivity Correlates with Functional Outcome in Acute Ischemic Stroke Patients" @default.
- W1599639232 doi "https://doi.org/10.1161/str.46.suppl_1.wp29" @default.
- W1599639232 hasPublicationYear "2015" @default.
- W1599639232 type Work @default.
- W1599639232 sameAs 1599639232 @default.
- W1599639232 citedByCount "0" @default.
- W1599639232 crossrefType "journal-article" @default.
- W1599639232 hasAuthorship W1599639232A5004519450 @default.
- W1599639232 hasAuthorship W1599639232A5012581799 @default.
- W1599639232 hasAuthorship W1599639232A5018286707 @default.
- W1599639232 hasAuthorship W1599639232A5020029507 @default.
- W1599639232 hasAuthorship W1599639232A5038140733 @default.
- W1599639232 hasAuthorship W1599639232A5048090321 @default.
- W1599639232 hasAuthorship W1599639232A5062109811 @default.
- W1599639232 hasAuthorship W1599639232A5076080475 @default.
- W1599639232 hasConcept C126322002 @default.
- W1599639232 hasConcept C126838900 @default.
- W1599639232 hasConcept C127413603 @default.
- W1599639232 hasConcept C135691158 @default.
- W1599639232 hasConcept C143409427 @default.
- W1599639232 hasConcept C146957229 @default.
- W1599639232 hasConcept C164705383 @default.
- W1599639232 hasConcept C2776572282 @default.
- W1599639232 hasConcept C2778820722 @default.
- W1599639232 hasConcept C2779581417 @default.
- W1599639232 hasConcept C2780645631 @default.
- W1599639232 hasConcept C2780931571 @default.
- W1599639232 hasConcept C3020166492 @default.
- W1599639232 hasConcept C3020199598 @default.
- W1599639232 hasConcept C500558357 @default.
- W1599639232 hasConcept C541997718 @default.
- W1599639232 hasConcept C71924100 @default.
- W1599639232 hasConcept C78519656 @default.
- W1599639232 hasConceptScore W1599639232C126322002 @default.
- W1599639232 hasConceptScore W1599639232C126838900 @default.
- W1599639232 hasConceptScore W1599639232C127413603 @default.
- W1599639232 hasConceptScore W1599639232C135691158 @default.
- W1599639232 hasConceptScore W1599639232C143409427 @default.
- W1599639232 hasConceptScore W1599639232C146957229 @default.
- W1599639232 hasConceptScore W1599639232C164705383 @default.
- W1599639232 hasConceptScore W1599639232C2776572282 @default.
- W1599639232 hasConceptScore W1599639232C2778820722 @default.
- W1599639232 hasConceptScore W1599639232C2779581417 @default.
- W1599639232 hasConceptScore W1599639232C2780645631 @default.
- W1599639232 hasConceptScore W1599639232C2780931571 @default.
- W1599639232 hasConceptScore W1599639232C3020166492 @default.
- W1599639232 hasConceptScore W1599639232C3020199598 @default.
- W1599639232 hasConceptScore W1599639232C500558357 @default.
- W1599639232 hasConceptScore W1599639232C541997718 @default.
- W1599639232 hasConceptScore W1599639232C71924100 @default.
- W1599639232 hasConceptScore W1599639232C78519656 @default.
- W1599639232 hasLocation W15996392321 @default.
- W1599639232 hasOpenAccess W1599639232 @default.
- W1599639232 hasPrimaryLocation W15996392321 @default.
- W1599639232 hasRelatedWork W1544147180 @default.
- W1599639232 hasRelatedWork W1568151787 @default.
- W1599639232 hasRelatedWork W1987285391 @default.
- W1599639232 hasRelatedWork W2136510344 @default.
- W1599639232 hasRelatedWork W2158657563 @default.
- W1599639232 hasRelatedWork W2253931519 @default.
- W1599639232 hasRelatedWork W2260850739 @default.
- W1599639232 hasRelatedWork W2289614499 @default.
- W1599639232 hasRelatedWork W2291626880 @default.
- W1599639232 hasRelatedWork W2307041533 @default.
- W1599639232 hasRelatedWork W2372394027 @default.
- W1599639232 hasRelatedWork W2375135777 @default.
- W1599639232 hasRelatedWork W2568563371 @default.
- W1599639232 hasRelatedWork W2620742319 @default.
- W1599639232 hasRelatedWork W2731282913 @default.
- W1599639232 hasRelatedWork W2755207113 @default.
- W1599639232 hasRelatedWork W2912186209 @default.
- W1599639232 hasRelatedWork W3153455061 @default.
- W1599639232 hasRelatedWork W3167364476 @default.
- W1599639232 hasRelatedWork W2740200225 @default.
- W1599639232 isParatext "false" @default.
- W1599639232 isRetracted "false" @default.
- W1599639232 magId "1599639232" @default.
- W1599639232 workType "article" @default.