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- W159968576 abstract "B-cells play a major role in the immunopathogenesis of autoimmune diseases. Not only do they produce autoantibodies, but they regulate other cell types, secrete cytokines, and present antigens. They are thus potential targets for therapeutic intervention. CD20 is a B-cell specific cell surface molecule of uncertain function. An anti-CD20 chimeric mAb (rituximab) has been FDA approved for treatment of B-cell lymphomas since 1997. Rituximab also depletes normal B-cells by several mechanisms, including ADCC. Over the past seven years, it has shown promise in a number of autoimmune diseases in phase I trials and anecdotal reports. Efficacy in rheumatoid arthritis has already been demonstrated in randomized control trials (RCTs), and RCTs in SLE, inflammatory myositis, and ANCA associated vasculitis are under way. Safety does not appear to be a major problem, but continued vigilance is warranted. The increased use of rituximab, other anti-CD20 agents, and other B-cell targeting therapies holds great promise for substantial clinical benefits, as well as providing special opportunities to understand better disease pathogenesis." @default.
- W159968576 created "2016-06-24" @default.
- W159968576 creator A5026480550 @default.
- W159968576 creator A5059625679 @default.
- W159968576 date "2005-12-01" @default.
- W159968576 modified "2023-10-07" @default.
- W159968576 title "The therapeutic potential of anti-CD20" @default.
- W159968576 cites W1509374036 @default.
- W159968576 cites W1515279716 @default.
- W159968576 cites W1519556180 @default.
- W159968576 cites W1524901905 @default.
- W159968576 cites W1534748037 @default.
- W159968576 cites W1578536091 @default.
- W159968576 cites W1580997941 @default.
- W159968576 cites W1592990112 @default.
- W159968576 cites W1625166229 @default.
- W159968576 cites W1633176708 @default.
- W159968576 cites W1642392901 @default.
- W159968576 cites W1656960246 @default.
- W159968576 cites W1675831178 @default.
- W159968576 cites W1685882185 @default.
- W159968576 cites W1854005499 @default.
- W159968576 cites W1881313440 @default.
- W159968576 cites W1903287340 @default.
- W159968576 cites W1914229355 @default.
- W159968576 cites W1966122623 @default.
- W159968576 cites W1968241220 @default.
- W159968576 cites W1969467075 @default.
- W159968576 cites W1972073735 @default.
- W159968576 cites W1972121328 @default.
- W159968576 cites W1974283070 @default.
- W159968576 cites W1979336667 @default.
- W159968576 cites W1981933562 @default.
- W159968576 cites W1996373638 @default.
- W159968576 cites W2004961788 @default.
- W159968576 cites W2011261778 @default.
- W159968576 cites W2011346484 @default.
- W159968576 cites W2014987748 @default.
- W159968576 cites W2017709470 @default.
- W159968576 cites W2019710876 @default.
- W159968576 cites W2020793885 @default.
- W159968576 cites W2027374210 @default.
- W159968576 cites W2032454178 @default.
- W159968576 cites W2033485934 @default.
- W159968576 cites W2035277855 @default.
- W159968576 cites W2041873257 @default.
- W159968576 cites W2044360617 @default.
- W159968576 cites W2046059252 @default.
- W159968576 cites W2046468905 @default.
- W159968576 cites W2050243165 @default.
- W159968576 cites W2057194530 @default.
- W159968576 cites W2057796652 @default.
- W159968576 cites W2060041600 @default.
- W159968576 cites W2060064772 @default.
- W159968576 cites W2060259319 @default.
- W159968576 cites W2061698567 @default.
- W159968576 cites W2062186653 @default.
- W159968576 cites W2062964758 @default.
- W159968576 cites W2065316818 @default.
- W159968576 cites W2065900855 @default.
- W159968576 cites W2071127094 @default.
- W159968576 cites W2071499539 @default.
- W159968576 cites W2072882391 @default.
- W159968576 cites W2075632612 @default.
- W159968576 cites W2079756029 @default.
- W159968576 cites W2084547554 @default.
- W159968576 cites W2085242627 @default.
- W159968576 cites W2085425556 @default.
- W159968576 cites W2089016290 @default.
- W159968576 cites W2096055205 @default.
- W159968576 cites W2099314298 @default.
- W159968576 cites W2116095933 @default.
- W159968576 cites W2118994799 @default.
- W159968576 cites W2122507029 @default.
- W159968576 cites W2126746651 @default.
- W159968576 cites W2130945067 @default.
- W159968576 cites W2132433919 @default.
- W159968576 cites W2140102724 @default.
- W159968576 cites W2141219630 @default.
- W159968576 cites W2145188316 @default.
- W159968576 cites W2147048607 @default.
- W159968576 cites W2151703174 @default.
- W159968576 cites W2153385611 @default.
- W159968576 cites W2155086276 @default.
- W159968576 cites W2157130851 @default.
- W159968576 cites W2159257554 @default.
- W159968576 cites W2164819810 @default.
- W159968576 cites W2165330836 @default.
- W159968576 cites W2168495534 @default.
- W159968576 cites W2316061195 @default.
- W159968576 cites W33733012 @default.
- W159968576 cites W4238040389 @default.
- W159968576 cites W75102634 @default.
- W159968576 doi "https://doi.org/10.1016/j.clim.2005.08.006" @default.
- W159968576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16169773" @default.
- W159968576 hasPublicationYear "2005" @default.
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