Matches in SemOpenAlex for { <https://semopenalex.org/work/W1599687093> ?p ?o ?g. }
- W1599687093 abstract "Abstract In this article, various electrochemical methods used in neuronal cell studies are examined. Electrochemical methods useful for investigating neuronal communication directly in the brain and in ex vivo brain slices are discussed. Additionally, we describe how voltammetric methods can be used to make intracellular and extracellular measurements at single cells. Technical aspects of each method are emphasized and selected applications are highlighted. Although techniques such as electron microscopy and patch clamp can be used to visualize and monitor cellular events, electrochemical methods can provide chemical information about neurotransmitters being released and transported in brain tissue or even at single cells. The main competing technique for in vivo measurements of neurotransmitters is microdialysis. Although microdialysis coupled to separation techniques can be more selective and more sensitive than electrochemical methods, the latter methods are considerably faster and more accurate in determining the in vivo concentration. At single cells, electrochemistry provides extremely small probes compared to microdialysis thus facilitating measurements of single‐cell events. Here, again, the response time associated with electrochemical methods is important for measurements of millisecond exocytosis events. Electrochemical methods are clearly a powerful means to measure rapid changes in neurotransmitters that are electroactive and found in tissue or cellular microenvironments." @default.
- W1599687093 created "2016-06-24" @default.
- W1599687093 creator A5008847450 @default.
- W1599687093 creator A5046460191 @default.
- W1599687093 date "2000-10-30" @default.
- W1599687093 modified "2023-10-10" @default.
- W1599687093 title "Neurotransmitters, Electrochemical Detection of" @default.
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