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• W1599691685 abstract "Gastrointestinal secretion and absorption of nutrients diminish with ageing, as does gastrointestinal motility, whereas the incidence of gastrointestinal complaints such as reflux esophagitis, earlier satiety, nausea and vomiting, and constipation increases. The gut neuroendocrine system regulates the gastrointestinal functions, which are disturbed in the elderly, namely secretion, absorption and motility. It is therefore conceivable that age-related changes take place, contributing to the development of the gastrointestinal disorders seen in the elderly and to the manifestation of the gastrointestinal symptoms. Age-related changes in the gut neuroendocrine system are both numerous and complicated. It is difficult to distinguish between those that are due to the inevitable process of ageing itself, and those that are secondary (adaptive) to them. Ageing is accompanied by a general loss of neurons of the enteric nervous system and a change in the density of gastrointestinal endocrine cells. These, together with structural and functional changes in the gut and associated glands, may cause the adaptive changes in the enteric nervous system and the gut endocrine cells that have been reported to have a great capacity of plasticity. The accumulated data on the changes in gastrointestinal neuroendocrine system during ageing could prove useful in clinical practice. Thus, a diet that regulates the release of a certain signal substance of this regulatory system could be used to induce a desirable increase or a reduction in this substance. Furthermore, an agonist or antagonist to the gut neuroendocrine system could be utilized." @default.
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• W1599691685 date "2004-01-01" @default.
• W1599691685 modified "2023-10-16" @default.
• W1599691685 title "Ageing and the Neuroendocrine System of the Gut" @default.
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• W1599691685 doi "https://doi.org/10.1016/s1567-7443(04)80017-6" @default.
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